Lyophilization as a Method for Stabilizing Pharmaceuticals

L. L. Nikolaeva; I. D. Gulyakin; O. L. Orlova; A. P. Polozkova; N. A. Oborotova; E. V. Sanarova; A. V. Lantsova; V. V. Khlamov; N. D. Bunyatyan

doi:10.1007/s11094-017-1604-5

Lyophilization as a Method for Stabilizing Pharmaceuticals

Авторы: Nikolaeva L.L.¹, Gulyakin I.D.¹, Orlova O.L.¹, Polozkova A.P.¹, Oborotova N.A.¹^,2, Sanarova E.V.¹, Lantsova A.V.¹, Khlamov V.V.¹, Bunyatyan N.D.²
Учреждения:
1. N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences
2. Sechenov First Moscow State Medical University
Выпуск: Том 51, № 4 (2017)
Страницы: 307-311
Раздел: Drug Synthesis Methods and Manufacturing Technology
URL: https://ogarev-online.ru/0091-150X/article/view/244584
DOI: https://doi.org/10.1007/s11094-017-1604-5
ID: 244584

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Аннотация

Lyophilization (freeze drying) is among the most effective methods used to stabilize drugs and increase their shelf life. It is influenced by many factors, the most important of which are the properties of the parent drug substance and the excipients and the freezing and drying conditions. This review considers in detail the excipients used in lyophilized dosage forms and gives examples of sublimation regimes used for the lyophilization of some antitumor drugs.