Email this article Lyophilization as a Method for Stabilizing Pharmaceuticals
- Authors: Nikolaeva L.L.1, Gulyakin I.D.1, Orlova O.L.1, Polozkova A.P.1, Oborotova N.A.1,2, Sanarova E.V.1, Lantsova A.V.1, Khlamov V.V.1, Bunyatyan N.D.2
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Affiliations:
- N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences
- Sechenov First Moscow State Medical University
- Issue: Vol 51, No 4 (2017)
- Pages: 307-311
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://ogarev-online.ru/0091-150X/article/view/244584
- DOI: https://doi.org/10.1007/s11094-017-1604-5
- ID: 244584
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Abstract
Lyophilization (freeze drying) is among the most effective methods used to stabilize drugs and increase their shelf life. It is influenced by many factors, the most important of which are the properties of the parent drug substance and the excipients and the freezing and drying conditions. This review considers in detail the excipients used in lyophilized dosage forms and gives examples of sublimation regimes used for the lyophilization of some antitumor drugs.
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About the authors
L. L. Nikolaeva
N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences
Email: chem@folium.ru
Russian Federation, 24 Kashirskoe Shosse, Moscow, 115478
I. D. Gulyakin
N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences
Email: chem@folium.ru
Russian Federation, 24 Kashirskoe Shosse, Moscow, 115478
O. L. Orlova
N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences
Email: chem@folium.ru
Russian Federation, 24 Kashirskoe Shosse, Moscow, 115478
A. P. Polozkova
N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences
Email: chem@folium.ru
Russian Federation, 24 Kashirskoe Shosse, Moscow, 115478
N. A. Oborotova
N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences; Sechenov First Moscow State Medical University
Email: chem@folium.ru
Russian Federation, 24 Kashirskoe Shosse, Moscow, 115478; Moscow, 119991
E. V. Sanarova
N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences
Email: chem@folium.ru
Russian Federation, 24 Kashirskoe Shosse, Moscow, 115478
A. V. Lantsova
N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences
Email: chem@folium.ru
Russian Federation, 24 Kashirskoe Shosse, Moscow, 115478
V. V. Khlamov
N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences
Email: chem@folium.ru
Russian Federation, 24 Kashirskoe Shosse, Moscow, 115478
N. D. Bunyatyan
Sechenov First Moscow State Medical University
Email: chem@folium.ru
Russian Federation, Moscow, 119991
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