Cytotoxicity of New Ferulic-Acid Derivatives on Human Colon Carcinoma (HCT116) Cells


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Resumo

A series of esters of ferulic acid and alcohols were synthesized and characterized structurally. All tested synthetic compounds were more cytotoxic against HCT116 cell line (human colon carcinoma) than ferulic acid. Benzyl and phenylethyl esters of ferulic acid were the most active compounds (IC50 = 0.0077 and 0.0065 g/L, respectively). Feruloylated wheat-bran oligosaccharides were less active than free ferulic acid against HCT116 tumor cells.

Sobre autores

L. Bakholdina

Biisk Technological Institute (Filial), I. I. Polzunov Altai State Technical University; Institute for Problems of Chemical and Energetic Technologies, Siberian Branch, Russian Academy of Sciences

Autor responsável pela correspondência
Email: ljuba27@mail.ru
Rússia, 27 Trofimov St., Biisk, Altai Krai, 659305; Biisk, Altai Krai, 659322

A. Markova

A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Email: ljuba27@mail.ru
Rússia, Moscow, 119991

A. Khlebnikov

National Research Tomsk Polytechnic University

Email: ljuba27@mail.ru
Rússia, Tomsk, 634050

V. Sevodin

Biisk Technological Institute (Filial), I. I. Polzunov Altai State Technical University

Email: ljuba27@mail.ru
Rússia, 27 Trofimov St., Biisk, Altai Krai, 659305

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