Enviar artigo por via de e-mail Development of a Dosage Form of the New Antitumor Antibiotic Olivamide
- Autores: Tevyashova A.N.1,2, Bychkova E.N.1, Dezhenkova L.G.1, Shchekotikhin A.E.1,2
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Afiliações:
- G. F. Gause Institute of New Antibiotics (GINA)
- D. Mendeleev University of Chemical Technology of Russia
- Edição: Volume 52, Nº 11 (2019)
- Páginas: 930-935
- Seção: Drug Synthesis Methods and Manufacturing Technology
- URL: https://ogarev-online.ru/0091-150X/article/view/245540
- DOI: https://doi.org/10.1007/s11094-019-01928-x
- ID: 245540
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Resumo
Methods for selective chemical modification of the antitumor antibiotic olivomycin A(OA) were developed at GINA. The compound olivamide with advantages over starting OA was selected from series of OA analogs. The goal of the present work was to develop a dosage form of the antitumor semi-synthetic antibiotic olivamide that guaranteed the stability and high specific activity of olivamide drug substance and was designed for further comprehensive preclinical studies.
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Sobre autores
A. Tevyashova
G. F. Gause Institute of New Antibiotics (GINA); D. Mendeleev University of Chemical Technology of Russia
Autor responsável pela correspondência
Email: chulis@mail.ru
Rússia, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021; 9 Miusskaya Sq., Moscow, 125047
E. Bychkova
G. F. Gause Institute of New Antibiotics (GINA)
Email: chulis@mail.ru
Rússia, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021
L. Dezhenkova
G. F. Gause Institute of New Antibiotics (GINA)
Email: chulis@mail.ru
Rússia, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021
A. Shchekotikhin
G. F. Gause Institute of New Antibiotics (GINA); D. Mendeleev University of Chemical Technology of Russia
Email: chulis@mail.ru
Rússia, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021; 9 Miusskaya Sq., Moscow, 125047
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