Мақаланы E-mail арқылы жіберу Development of a Dosage Form of the New Antitumor Antibiotic Olivamide
- Авторлар: Tevyashova A.N.1,2, Bychkova E.N.1, Dezhenkova L.G.1, Shchekotikhin A.E.1,2
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Мекемелер:
- G. F. Gause Institute of New Antibiotics (GINA)
- D. Mendeleev University of Chemical Technology of Russia
- Шығарылым: Том 52, № 11 (2019)
- Беттер: 930-935
- Бөлім: Drug Synthesis Methods and Manufacturing Technology
- URL: https://ogarev-online.ru/0091-150X/article/view/245540
- DOI: https://doi.org/10.1007/s11094-019-01928-x
- ID: 245540
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Аннотация
Methods for selective chemical modification of the antitumor antibiotic olivomycin A(OA) were developed at GINA. The compound olivamide with advantages over starting OA was selected from series of OA analogs. The goal of the present work was to develop a dosage form of the antitumor semi-synthetic antibiotic olivamide that guaranteed the stability and high specific activity of olivamide drug substance and was designed for further comprehensive preclinical studies.
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Авторлар туралы
A. Tevyashova
G. F. Gause Institute of New Antibiotics (GINA); D. Mendeleev University of Chemical Technology of Russia
Хат алмасуға жауапты Автор.
Email: chulis@mail.ru
Ресей, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021; 9 Miusskaya Sq., Moscow, 125047
E. Bychkova
G. F. Gause Institute of New Antibiotics (GINA)
Email: chulis@mail.ru
Ресей, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021
L. Dezhenkova
G. F. Gause Institute of New Antibiotics (GINA)
Email: chulis@mail.ru
Ресей, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021
A. Shchekotikhin
G. F. Gause Institute of New Antibiotics (GINA); D. Mendeleev University of Chemical Technology of Russia
Email: chulis@mail.ru
Ресей, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021; 9 Miusskaya Sq., Moscow, 125047
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