Email this article Development of a Dosage Form of the New Antitumor Antibiotic Olivamide
- Authors: Tevyashova A.N.1,2, Bychkova E.N.1, Dezhenkova L.G.1, Shchekotikhin A.E.1,2
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Affiliations:
- G. F. Gause Institute of New Antibiotics (GINA)
- D. Mendeleev University of Chemical Technology of Russia
- Issue: Vol 52, No 11 (2019)
- Pages: 930-935
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://ogarev-online.ru/0091-150X/article/view/245540
- DOI: https://doi.org/10.1007/s11094-019-01928-x
- ID: 245540
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Abstract
Methods for selective chemical modification of the antitumor antibiotic olivomycin A(OA) were developed at GINA. The compound olivamide with advantages over starting OA was selected from series of OA analogs. The goal of the present work was to develop a dosage form of the antitumor semi-synthetic antibiotic olivamide that guaranteed the stability and high specific activity of olivamide drug substance and was designed for further comprehensive preclinical studies.
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About the authors
A. N. Tevyashova
G. F. Gause Institute of New Antibiotics (GINA); D. Mendeleev University of Chemical Technology of Russia
Author for correspondence.
Email: chulis@mail.ru
Russian Federation, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021; 9 Miusskaya Sq., Moscow, 125047
E. N. Bychkova
G. F. Gause Institute of New Antibiotics (GINA)
Email: chulis@mail.ru
Russian Federation, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021
L. G. Dezhenkova
G. F. Gause Institute of New Antibiotics (GINA)
Email: chulis@mail.ru
Russian Federation, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021
A. E. Shchekotikhin
G. F. Gause Institute of New Antibiotics (GINA); D. Mendeleev University of Chemical Technology of Russia
Email: chulis@mail.ru
Russian Federation, 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021; 9 Miusskaya Sq., Moscow, 125047
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