Experience in the Use of Solid-Phase Extraction in the Screening of Pharmaceuticals and Narcotics in the Blood by Gas Chromatography with Mass Spectrometric Detection

Resumo

Studies using 224 blood samples as examples showed that the use of solid-phase extraction and gas chromatography with mass spectrometric detection for screening blood provides reliable identification of a wide range of narcotic and pharmaceutical substances of forensic medical interest, including “designer” synthetic narcotics – methylenedioxypyrovalerone (MDPV), pyrrolidinovalerophenone (PVP), and their metabolites; cannabimimetic metabolites N-(1-carbamoyl-2-methylpropyl)-1-pentyl-1H-indazole-3-carboxamide (ABPINACA) and/or N-[(1-pentyl-1H-indazol-3-yl)carbonyl]valine methyl ester (AMB). The distribution of substances in different elusion fractions is given and dissociation constants (pK_a) and coefficients of distribution in an octanol-water system (log P) are calculated.