Validation of a Method for Measuring the Molar Substitution of Hydroxyethylstarches by  1 H NMR Spectroscopy

N. E. Kuz’mina; S. V. Moiseev; V. I. Krylov; V. A. Yashkir; V. A. Merkulov

doi:10.1007/s11094-016-1435-9

Validation of a Method for Measuring the Molar Substitution of Hydroxyethylstarches by ¹H NMR Spectroscopy

Autores: Kuz’mina N.E.¹, Moiseev S.V.¹, Krylov V.I.¹, Yashkir V.A.¹, Merkulov V.A.¹
Afiliações:
1. Scientific Center for Expert Evaluation of Medical Products, Russian Ministry of Health
Edição: Volume 50, Nº 4 (2016)
Páginas: 265-269
Seção: Article
URL: https://ogarev-online.ru/0091-150X/article/view/244358
DOI: https://doi.org/10.1007/s11094-016-1435-9
ID: 244358

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Resumo

Amethod for determining molar substitution of hydroxyethylstarches by ¹H NMR spectroscopy was validated in terms of specificity, linearity, correctness, precision, and range of application. The method can be used to evaluate the parameter “molar substitution” in the framework of pharmacological expert assessment of hydroxyethylstarches as components of medicines.

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hydroxyethylstarches, molar substitution, validation of method, ¹H NMR spectroscopy