Influence of N,N′-Substituted Piperazines on Cytolysis

Аннотация

The hemolytic activity of N,N′-substituted piperazines and their influence on the hemolytic process initiated by radiation (red LED, 653 nm) in the presence of radachlorin (RADA-FARMA, Russia) photosensitizer and on complement-dependent hemolysis were studied. All compounds did not cause human RBC lysis in the studied concentration range (0.15 – 3.0 mM) although dose-dependent inhibition of photo-induced hemolysis that manifested as an increase of the 50% lysis time was observed. The piperazine derivatives did not substantially influence RBC lysis by the activated complement. Therefore, the antihemolytic effect of the N,N’-substituted piperazines was due to their antioxidant activity.