Enviar artigo por via de e-mail Synthesis and Pharmacological Activity of 2,9-Disubstituted Imidazo[1,2-a]Benzimidazole Phenyl- and Alkylthiocarbamides
- Autores: Anisimova V.A.1, Zhukovskaya O.N.1, Spasov A.A.2,3,4, Kuznetsova V.A.2,3, Kosolapov V.A.2,3, Yakovlev D.S.2,4, Solov’eva O.A.2, Sorotskii D.V.3, Brigadirova A.A.2, Vorob’ev E.S.2
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Afiliações:
- Institute of Physical and Organic Chemistry, Southern Federal University
- Volgograd State Medical University
- Research Institute of Pharmacology, Volgograd State Medical University
- Volgograd Medical Scientific Center, Volgograd State Medical University
- Edição: Volume 49, Nº 10 (2016)
- Páginas: 653-656
- Seção: Search for New Drugs
- URL: https://ogarev-online.ru/0091-150X/article/view/244267
- DOI: https://doi.org/10.1007/s11094-016-1346-9
- ID: 244267
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Resumo
A series of phenyl- and alkylthiocarbamides were synthesized by the reaction of 2,9-disubstituted imidazo-[1,2-a]benzimidazoles with phenyl- and alkylisothiocyanates. The structures of the products were confirmed by elemental analysis and PMR spectroscopy. Some of the synthesized compounds were capable of inhibiting non-enzymatic glycosylation of proteins. The concentration dependences of the antiglycation effect of the most active substances and aminoguanidine were studied.
Sobre autores
V. Anisimova
Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Rússia, Rostov-on-Don, 344090
O. Zhukovskaya
Institute of Physical and Organic Chemistry, Southern Federal University
Autor responsável pela correspondência
Email: zhukowskaia.ol@yandex.ru
Rússia, Rostov-on-Don, 344090
A. Spasov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University; Volgograd Medical Scientific Center, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd, 400131; Volgograd, 400131; Volgograd, 400131
V. Kuznetsova
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd, 400131; Volgograd, 400131
V. Kosolapov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd, 400131; Volgograd, 400131
D. Yakovlev
Volgograd State Medical University; Volgograd Medical Scientific Center, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd, 400131; Volgograd, 400131
O. Solov’eva
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd, 400131
D. Sorotskii
Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd, 400131
A. Brigadirova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd, 400131
E. Vorob’ev
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd, 400131
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