Enviar artigo por via de e-mail Synthesis, Hydrolytic Stability, and Antileukemic Activity of Azacytidine Nucleoside Analogs
- Autores: Bozhok T.S.1, Kalinichenko E.N.1, Kuz’mitskii B.B.1, Golubeva M.B.1
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Afiliações:
- Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
- Edição: Volume 49, Nº 12 (2016)
- Páginas: 804-809
- Seção: Search for New Drugs
- URL: https://ogarev-online.ru/0091-150X/article/view/244296
- DOI: https://doi.org/10.1007/s11094-016-1375-4
- ID: 244296
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Resumo
New azacytidine nucleoside analogs with modified carbohydrate moieties were synthesized. Screening identified a highly active 2′-fluoro-containing azacytidine analog that could potentially be of interest as an agent for treating acute myelogenous leukemia and myelodysplastic syndrome.
Sobre autores
T. Bozhok
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Email: kalinichenko@iboch.bas-net.by
Belarus, 5/2 Akad. V. F. Kuprevicha St., Minsk, 220141
E. Kalinichenko
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Autor responsável pela correspondência
Email: kalinichenko@iboch.bas-net.by
Belarus, 5/2 Akad. V. F. Kuprevicha St., Minsk, 220141
B. Kuz’mitskii
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Email: kalinichenko@iboch.bas-net.by
Belarus, 5/2 Akad. V. F. Kuprevicha St., Minsk, 220141
M. Golubeva
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Email: kalinichenko@iboch.bas-net.by
Belarus, 5/2 Akad. V. F. Kuprevicha St., Minsk, 220141
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