Email this article Arrhenius Kinetics As a Bioactivity Assessment Criterion for Drug Substances and Excipients
- Authors: Levitskaya O.V.1, Syroeshkin A.V.1, Pleteneva T.V.1
-
Affiliations:
- Russian University of People’s Friendship, 8 Miklukho-Maklaya St.
- Issue: Vol 49, No 11 (2016)
- Pages: 779-781
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244291
- DOI: https://doi.org/10.1007/s11094-016-1370-9
- ID: 244291
Cite item
Open Access
Access granted
Subscription Access
Abstract
Arrhenius kinetic principles, in particular, Ea values, were used to assess the biological activity of drug substances in aqueous solutions with different D/H ratios. The obtained activation energies indicated that deuterium-depleted solutions had lower toxicity and biological activity.
Keywords
About the authors
O. V. Levitskaya
Russian University of People’s Friendship, 8 Miklukho-Maklaya St.
Author for correspondence.
Email: titorovicholga@gmail.com
Russian Federation, Moscow, 117198
A. V. Syroeshkin
Russian University of People’s Friendship, 8 Miklukho-Maklaya St.
Email: titorovicholga@gmail.com
Russian Federation, Moscow, 117198
T. V. Pleteneva
Russian University of People’s Friendship, 8 Miklukho-Maklaya St.
Email: titorovicholga@gmail.com
Russian Federation, Moscow, 117198
Supplementary files
