Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil

A. A. Spasov; A. N. Geisman; V. A. Kosolapov; D. A. Babkov; A. I. Rashchenko; V. A. Babkova; O. Yu. Zakhar’yashcheva; A. A. Ozerov

doi:10.1007/s11094-019-02047-3

Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil

Authors: Spasov A.A.¹^,2, Geisman A.N.¹^,2, Kosolapov V.A.¹, Babkov D.A.¹, Rashchenko A.I.¹, Babkova V.A.¹, Zakhar’yashcheva O.Y.¹, Ozerov A.A.¹^,2
Affiliations:
1. Volgograd State Medical University
2. Volgograd Medical Science Center
Issue: Vol 53, No 7 (2019)
Pages: 610-615
Section: Article
URL: https://ogarev-online.ru/0091-150X/article/view/245897
DOI: https://doi.org/10.1007/s11094-019-02047-3
ID: 245897

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Abstract

S-carboxyalkyl derivatives of 2-thiouracil were synthesized and their pharmacological activity was studied. Several of the compounds were characterized by antiglycation activity. These compounds had no effect on PPAR or glucokinase activity and had weak activity in cleaving protein crosslinks.