Мақаланы E-mail арқылы жіберу Synthesis and Neurotropic Activity of Piperazino-Derivatives of Pyrano[3,4-c]Pyridines
- Авторлар: Sirakanyan S.N.1, Akopyan É.K.1, Paronikyan R.G.1, Nazaryan I.M.1, Akopyan A.G.1, Ovakimyan A.A.1
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Мекемелер:
- A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
- Шығарылым: Том 53, № 6 (2019)
- Беттер: 495-499
- Бөлім: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245831
- DOI: https://doi.org/10.1007/s11094-019-02026-8
- ID: 245831
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Аннотация
Methods were developed for synthesizing new substituted piperazine derivatives from chloropyrano- [3,4-c]pyridines. Pharmacological screening of the synthesized compounds used the well-known corazole antagonism and open field tests. The rotating rod test was used to evaluate the neurotoxicity of the compounds. The tested compounds displayed neurotropic activity. Several compounds of this series exhibited pronounced anticonvulsant and anxiolytic activity.
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Авторлар туралы
S. Sirakanyan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Хат алмасуға жауапты Автор.
Email: shnnr@mail.ru
Армения, 0014, Yerevan, 375014
É. Akopyan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shnnr@mail.ru
Армения, 0014, Yerevan, 375014
R. Paronikyan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shnnr@mail.ru
Армения, 0014, Yerevan, 375014
I. Nazaryan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shnnr@mail.ru
Армения, 0014, Yerevan, 375014
A. Akopyan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shnnr@mail.ru
Армения, 0014, Yerevan, 375014
A. Ovakimyan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shnnr@mail.ru
Армения, 0014, Yerevan, 375014
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