Email this article Quantitative HPLC Determination of γ-Aminobutyric Acid Derivative Mefebut in Bioassays
- Authors: Smirnova L.A.1,2, Ryabukha A.F.1,2, Suchkov E.A.1,2, Kuznetsov K.A.1,2, Tyurenkov I.N.1, Bakulin D.A.1
-
Affiliations:
- Volgograd State Medical University
- Volgograd Medical Research Center
- Issue: Vol 53, No 3 (2019)
- Pages: 272-274
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245725
- DOI: https://doi.org/10.1007/s11094-019-01991-4
- ID: 245725
Cite item
Open Access
Access granted
Subscription Access
Abstract
A quantitative HPLC method was developed for analyzing mefebut in pharmacokinetic studies. The method was highly sensitive and selective and could be used for determinations in bioassays. The optimized sample-preparation method did not significantly influence the standard error of the quantitative determination.
Keywords
About the authors
L. A. Smirnova
Volgograd State Medical University; Volgograd Medical Research Center
Email: annriabuha@gmail.com
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131; 1 Pavshchikh Bortsov Sq., Volgograd, 400131
A. F. Ryabukha
Volgograd State Medical University; Volgograd Medical Research Center
Author for correspondence.
Email: annriabuha@gmail.com
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131; 1 Pavshchikh Bortsov Sq., Volgograd, 400131
E. A. Suchkov
Volgograd State Medical University; Volgograd Medical Research Center
Email: annriabuha@gmail.com
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131; 1 Pavshchikh Bortsov Sq., Volgograd, 400131
K. A. Kuznetsov
Volgograd State Medical University; Volgograd Medical Research Center
Email: annriabuha@gmail.com
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131; 1 Pavshchikh Bortsov Sq., Volgograd, 400131
I. N. Tyurenkov
Volgograd State Medical University
Email: annriabuha@gmail.com
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131
D. A. Bakulin
Volgograd State Medical University
Email: annriabuha@gmail.com
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131
Supplementary files
