Email this article Synthesis, Structure Elucidation and Antimicrobial Properties of New Bis-1,3,4-Oxadiazole Derivatives
- Authors: Rohand T.1, Ramli Y.2, Baruah M.3, Budka J.4, Das A.M.5
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Affiliations:
- Laboratoire de Chimie Analytique et Moléculaire, Département de Chimie, Université Cadi Ayyad, Faculté Polydisciplinaire Safi
- Laboratoire de ChimieThérapeutique, Université Mohamed V, Faculté de Médecineet de Pharmacie de Rabat
- Department of Chemistry, The Assam Kaziranga University
- Department of Organic Chemistry, University of Chemistry and Technology
- Natural Products Chemistry Division, CSIR, North East Institute of Science and Technology
- Issue: Vol 53, No 2 (2019)
- Pages: 150-154
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245647
- DOI: https://doi.org/10.1007/s11094-019-01969-2
- ID: 245647
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Abstract
Four new 1,3,4-bis-oxadiazole derivatives were synthesized, two of them bearing quaternary ammonium salts. The newly synthesized bis-1,3,4-oxadiazoles were investigated for their antibacterial activity against various Gram-positive and Gram-negative strains of bacteria. The target products were prepared from 2-(dimethylamino)ethyl methacrylate (DMAEMA) or 2-(diethylamino)ethyl methacrylate (DEAEMA) via reactions with hexanedioic acid. The structures of all synthesized compounds were confirmed by IR, 1H-NMR, and 13C-NMR spectroscopy. The results of biological activity testing showed that two compounds exhibited the best antibacterial activity against Citrobacterfreundii (ATCC 8090) and Methicillin-resistant Staphylococcus aureus (ATCC 43300) strains.
About the authors
Taoufik Rohand
Laboratoire de Chimie Analytique et Moléculaire, Département de Chimie, Université Cadi Ayyad, Faculté Polydisciplinaire Safi
Author for correspondence.
Email: Taoufik.Rohand@uca.ac.ma
Morocco, Safi
Youssef Ramli
Laboratoire de ChimieThérapeutique, Université Mohamed V, Faculté de Médecineet de Pharmacie de Rabat
Email: Taoufik.Rohand@uca.ac.ma
Morocco, Av Med Belarbi Elalaoui, BP 6203, Rabat-Institus, Rabat
Mukulesh Baruah
Department of Chemistry, The Assam Kaziranga University
Email: Taoufik.Rohand@uca.ac.ma
India, Karaikhowa, Jorhat, Assam, 785006
Jan Budka
Department of Organic Chemistry, University of Chemistry and Technology
Email: Taoufik.Rohand@uca.ac.ma
Czech Republic, Prague
Archana M. Das
Natural Products Chemistry Division, CSIR, North East Institute of Science and Technology
Email: Taoufik.Rohand@uca.ac.ma
India, Jorhat, Assam, 785006
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