Synthesis and Antiproliferative Activity of Daunorubicin Conjugates with Sesquiterpene Lactones

L. V. Anikina; A. V. Semakov; S. V. Afanas’eva; S. A. Pukhov; S. G. Klochkov

doi:10.1007/s11094-018-1812-7

Synthesis and Antiproliferative Activity of Daunorubicin Conjugates with Sesquiterpene Lactones

Authors: Anikina L.V.¹, Semakov A.V.¹, Afanas’eva S.V.¹, Pukhov S.A.¹, Klochkov S.G.¹
Affiliations:
1. Institute of Physiologically Active Compounds, Russian Academy of Sciences
Issue: Vol 52, No 4 (2018)
Pages: 308-311
Section: Article
URL: https://ogarev-online.ru/0091-150X/article/view/245151
DOI: https://doi.org/10.1007/s11094-018-1812-7
ID: 245151

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Abstract

The anthracycline antibiotic daunorubicin was modified by alantolactone, isoalantolactone, and alloahntolactone, i.e., sesquitapene lactones from Inula helenium L. The antiproliferative properties of the synthesized conjugates were studied using tumor and normal cell lines. It was found that the conjugate of daunorubicin with alantolactone possessed more pronounced antiproliferative properties than daunorubicin for several tumor cell cultures without increasing the toxicity for normal cells.