Email this article Preparation of Low-Molecular-Weight Heparins by Radiation-Induced Destruction
- Authors: Tuaeva N.O.1,2, Trukhan V.M.1, Kardonskii D.A.1, Eganov A.A.1, Grebenkina E.V.1, Veselov V.V.1
-
Affiliations:
- I. M. Sechenov First Moscow State Medical University
- Kazan State Medical Academy, Branch of the Russian Medical Academy for Continuing Professional Education, Ministry of Health of the Russian Federation
- Issue: Vol 52, No 2 (2018)
- Pages: 122-126
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://ogarev-online.ru/0091-150X/article/view/245023
- DOI: https://doi.org/10.1007/s11094-018-1776-7
- ID: 245023
Cite item
Open Access
Access granted
Subscription Access
Abstract
Low-molecular-weight heparins (LMWHs) are widely used in medical practice. LMWHs are produced using various methods of controlled depolymerization of unfractionated heparin (UFH). Herein, a method for radiation-induced destruction of aqueous heparin solutions using a 60Co gamma-irradiation source is presented. The optimal conditions for depolymerization of starting heparin were found. The anticoagulant activity of LMWHs was studied as a function of irradiation dose. The results allowed this LMWH production method to be recommended for development of new anticoagulants.
About the authors
N. O. Tuaeva
I. M. Sechenov First Moscow State Medical University; Kazan State Medical Academy, Branch of the Russian Medical Academy for Continuing Professional Education, Ministry of Health of the Russian Federation
Author for correspondence.
Email: chemtox@mail.ru
Russian Federation, Moscow, 119991; Kazan, Tatarstan, 420012
V. M. Trukhan
I. M. Sechenov First Moscow State Medical University
Email: chemtox@mail.ru
Russian Federation, Moscow, 119991
D. A. Kardonskii
I. M. Sechenov First Moscow State Medical University
Email: chemtox@mail.ru
Russian Federation, Moscow, 119991
A. A. Eganov
I. M. Sechenov First Moscow State Medical University
Email: chemtox@mail.ru
Russian Federation, Moscow, 119991
E. V. Grebenkina
I. M. Sechenov First Moscow State Medical University
Email: chemtox@mail.ru
Russian Federation, Moscow, 119991
V. V. Veselov
I. M. Sechenov First Moscow State Medical University
Email: chemtox@mail.ru
Russian Federation, Moscow, 119991
Supplementary files
