Prospects of a Search for Kappa-Opioid Receptor Agonists with Analgesic Activity (Review)
- 作者: Zaitseva N.I.1, Galan S.E.1, Pavlova L.A.1
- 
							隶属关系: 
							- Research Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University
 
- 期: 卷 51, 编号 10 (2018)
- 页面: 843-851
- 栏目: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://ogarev-online.ru/0091-150X/article/view/244828
- DOI: https://doi.org/10.1007/s11094-018-1703-y
- ID: 244828
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详细
Current approaches to the search for new kappa-opioid receptor (κ-OR) agonists with potential analgesic activity are reviewed. Agents with peripheral activity and biased agonists are most promising for development. Signal events initiated by κ-OR activation are considered. Chemical structures of presently known κ-OR agonists are presented.
作者简介
N. Zaitseva
Research Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University
							编辑信件的主要联系方式.
							Email: nzaitseva@gmail.com
				                					                																			                												                	俄罗斯联邦, 							8/2 Trubetskaya St., Moscow, 119991						
S. Galan
Research Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University
														Email: nzaitseva@gmail.com
				                					                																			                												                	俄罗斯联邦, 							8/2 Trubetskaya St., Moscow, 119991						
L. Pavlova
Research Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University
														Email: nzaitseva@gmail.com
				                					                																			                												                	俄罗斯联邦, 							8/2 Trubetskaya St., Moscow, 119991						
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