Synthesis, Conversions, and Anti-Monoamine-Oxidase and Anticonvulsant Activity of Ethyl 4′-Amino-5′,8′-Dimethyl-1′H-Spiro[Cyclohexane-1,2′-Naphthalene]-3′-Carboxylate

Abstract

7,10-Dimethyl-2-thioxo-2,3-dihydro-1H-spiro[benzo[h]quinazoline-5,1′-cyclohexane]-4(6H)-one was synthesized from ethyl 4′-amino-5′,8′-dimethyl-1′H-spiro[cyclohexane-1,2′-naphthalene]-3′-carboxylate and reacted with various alkyl(benzyl)halides to afford a new series of benzo[h]quinazolines containing methyl substituents on the benzene ring. The anti-monoamine-oxidase and anticonvulsant activities of the benzo[h]quinazolines were studied.