Synthesis, Structure, and Anticaries Activity of 2-Amino-4,6-Dihydroxypyrimidinium Hexafluorosilicate
- Authors: Gel’mbol’dt V.O.1, Anisimov V.Y.1, Shishkin I.O.1, Fonar’ M.S.2, Kravtsov V.K.2
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Affiliations:
- Odessa National Medical University
- Institute of Applied Physics, Academy of Sciences of the Republic of Moldova
- Issue: Vol 52, No 7 (2018)
- Pages: 606-610
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245366
- DOI: https://doi.org/10.1007/s11094-018-1868-4
- ID: 245366
Cite item
Abstract
We report here the synthesis and our studies of the structure, physicochemical properties, and anticaries activity of a novel potential anticaries substance 2-amino-4,6-dihydroxypyrimidinium hexafluorosilicate. IR spectra, EI mass spectra, and 19F NMR spectra were obtained and their properties were studied. Biological investigations were performed on animals kept on the Stephan caries-inducing diet (50% sucrose). Alkaline phosphatase (AlkP) and acid phosphatatase (AcP) were assayed in pulp homogenates and the AlkP:AcP ratio was used to assess the mineralization index (MI). AlkP activity was measured in serum, along with alanine aminotransferase (ALT). The number and depth of caries lesions to the teeth were assessed and caries prophylactic efficacy (CPE) was computed. The data showed that 2-amino-4,6-dihydroxypyrimidinium hexafluorosilicate decreased the number of caries lesions by 45.5% and had high anticaries efficacy, five times greater than that of sodium fluoride.
About the authors
V. O. Gel’mbol’dt
Odessa National Medical University
Author for correspondence.
Email: vgelmboldt@te.net.ua
Ukraine, Odessa
V. Yu. Anisimov
Odessa National Medical University
Email: vgelmboldt@te.net.ua
Ukraine, Odessa
I. O. Shishkin
Odessa National Medical University
Email: vgelmboldt@te.net.ua
Ukraine, Odessa
M. S. Fonar’
Institute of Applied Physics, Academy of Sciences of the Republic of Moldova
Email: vgelmboldt@te.net.ua
Moldova, Republic of, Kishinev
V. Kh. Kravtsov
Institute of Applied Physics, Academy of Sciences of the Republic of Moldova
Email: vgelmboldt@te.net.ua
Moldova, Republic of, Kishinev
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