Comparison of Spectrophotometric and Chromatographic (HPLC) Procedures for Determining 3-Phenethylrhodanine Drug Substance with Anticancer Activity

N. E. Novozhilova; N. N. Kutina; Yu. Ya. Kharitonov

doi:10.1007/s11094-018-1782-9

Comparison of Spectrophotometric and Chromatographic (HPLC) Procedures for Determining 3-Phenethylrhodanine Drug Substance with Anticancer Activity

Authors: Novozhilova N.E.¹, Kutina N.N.¹, Kharitonov Y.Y.²
Affiliations:
1. Medbiopharm Innovation Company
2. I. M. Sechenov First Moscow Medical University
Issue: Vol 52, No 2 (2018)
Pages: 156-158
Section: Article
URL: https://ogarev-online.ru/0091-150X/article/view/245042
DOI: https://doi.org/10.1007/s11094-018-1782-9
ID: 245042

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Abstract

A comparison of spectrophotometric and chromatographic (HPLC) procedures for determining 3-phenethylrhodanine (cyclo-2-phenethyldithiocarbanoylacetic acid, CPET) drug substance using experimental and computational statistical methods showed that both methods had good precision and accuracy and could be recommended as equivalent alternative methods for quantitative determination of CPET drug substance.