Email this article Synthesis and Cytotoxic Activity of Arylsubstituted Tetrazolocyclanopyrimidines
- Authors: Vasil’kova N.O.1, Ivonin M.A.1, Burygin G.L.2, Prilepskii A.Y.2, Kriven’ko A.P.1
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Affiliations:
- N. G. Chernyshevskii Saratov State National Research University
- Institute of Plant and Microbial Biochemistry and Physiology
- Issue: Vol 51, No 9 (2017)
- Pages: 756-759
- Section: The Search for New Drugs
- URL: https://ogarev-online.ru/0091-150X/article/view/244789
- DOI: https://doi.org/10.1007/s11094-017-1687-z
- ID: 244789
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Abstract
A series of arylsubstituted tetrazolocyclanodihydropyrimidines was prepared and their cytotoxic actions on SPEV-2 cells were studied. The activity of these substances was found to depend on the nature and position of the substitution groups in the benzene ring and the size of the alicycle. The most active compounds were o-chloro(methyl)phenyltetrazolohexahydroquinazolines.
About the authors
N. O. Vasil’kova
N. G. Chernyshevskii Saratov State National Research University
Email: chem@folium.ru
Russian Federation, Saratov
M. A. Ivonin
N. G. Chernyshevskii Saratov State National Research University
Email: chem@folium.ru
Russian Federation, Saratov
G. L. Burygin
Institute of Plant and Microbial Biochemistry and Physiology
Email: chem@folium.ru
Russian Federation, Saratov
A. Yu. Prilepskii
Institute of Plant and Microbial Biochemistry and Physiology
Email: chem@folium.ru
Russian Federation, Saratov
A. P. Kriven’ko
N. G. Chernyshevskii Saratov State National Research University
Email: chem@folium.ru
Russian Federation, Saratov
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