Мақаланы E-mail арқылы жіберу Antitumor Activity of a Polymer Composite of Etoposide and Biodegradable Poly(Lactide-Co-Glycolide)
- Авторлар: Semochkina Y.P.1, Perevozchikova V.G.1, Moskaleva E.Y.1, Ratushnyak M.G.1, Vorontsov E.A.1, Kuznetsov S.L.1, Tubasheva I.A.1, Murav’eva A.I.1, Severin S.E.1, Posypanova G.A.1, Gorshkova L.B.1, Rodina A.V.1
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Мекемелер:
- National Research Centre Kurchatov Institute
- Шығарылым: Том 50, № 8 (2016)
- Беттер: 543-547
- Бөлім: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244433
- DOI: https://doi.org/10.1007/s11094-016-1486-y
- ID: 244433
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
A method for preparing an antitumor polymer form of etoposide (PFE) as submicron particles based on poly(lactide-co-glycolide) with a 50:50 ratio of monomers (PLGA 50/50) was described. It was shown that the PFE possessed high cytotoxicity against various types of human tumor cells. The activity of the PFE against multiple drug resistant K562ADR cell line was greater than that of free etoposide. A grafted solid P388 murine lymphatic leukemia model showed that the PFE exhibited high in vivo antitumor activity that was prolonged compared with that of free etoposide.
Негізгі сөздер
Авторлар туралы
Yu. Semochkina
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
V. Perevozchikova
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
E. Moskaleva
National Research Centre Kurchatov Institute
Хат алмасуға жауапты Автор.
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
M. Ratushnyak
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
E. Vorontsov
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
S. Kuznetsov
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
I. Tubasheva
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
A. Murav’eva
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
S. Severin
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
G. Posypanova
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
L. Gorshkova
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
A. Rodina
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
Ресей, 1 Akad. Kurchatov Sq., Moscow, 123182
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