Synthesis and Biological Activity of Low-Molecular-Mass Polypeptides Isolated From Extracellular Matrix of Bone Tissue

Abstract

The biological properties of low-molecular-mass polypeptides isolated from the extracellular matrix of bone tissues were studied using healing of a fractured rat tibia as a model. It was found that a single injection of the test fraction near the fracture caused glycogen to accumulate and the sarcoplasmic protein content to increase in skeletal muscle of the traumatized extremity section. The healing time of the experimental fracture in rats was shortened. The results justify the creation of complex preparations designed to promote regeneration of support tissues that are composed of low-molecular-mass derivatives of collagen + growth factors.