Experimental Study of the Biocompatibility of Soft Tissues and a Finely Dispersed Sorbent Containing Silver


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The physicochemical and biological properties of a new finely dispersed Si- and Al-containing sorbent are presented. Its modification using silver nanoclusters immobilized on the sorbent-particle surface is described. The parameters of the sorbent porous structure, its sorption activity, and the rate of silver release from the sorbent surface in contact with a liquid medium are determined. Both the sorbent matrix and the original silver-modified sorbent are well tolerated by experimental animals upon intramuscular administration and cause no changes in the behavior, weight, and appearance of the animals. Results from studies of the leukocyte, platelet, and red-blood-cell pools of peripheral blood also confirm that the sorbents are biocompatible with body tissues.

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T. Popova

Institute of Clinical and Experimental Lymphology

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Email: argentum.popova@mail.ru
俄罗斯联邦, Novosibirsk, 630117

T. Tolstikova

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences

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Email: tg_tolstikova@mail.ru
俄罗斯联邦, Novosibirsk, 630090

A. Letyagin

Institute of Clinical and Experimental Lymphology

Email: tg_tolstikova@mail.ru
俄罗斯联邦, Novosibirsk, 630117

L. Rachkovskaya

Institute of Clinical and Experimental Lymphology

Email: tg_tolstikova@mail.ru
俄罗斯联邦, Novosibirsk, 630117

V. Burmistrov

Institute of Clinical and Experimental Lymphology

Email: tg_tolstikova@mail.ru
俄罗斯联邦, Novosibirsk, 630117

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