Multi-Day Monitoring of Ubidecarenone Level in Rat Plasma and Tissues After a Single Intravenous Injection

Abstract

The pharmacokinetics of ubidecarenone (CoQ10) in rat plasma and the kinetics of its organ levels were studied for the first time for 8-16 d after a single i.v. injection at a dose of 30 mg/kg. The pharmacokinetics followed a classical two-compartment curve. The main pharmacokinetic parameters for plasma (C₀, AUC_0→∞, K_α, K_el, t_1/2α, t_1/2el, Cl_T, V_d) and several organs (C_max, T_max, AUC_0→t, f_tiss) were calculated. The results proved that CoQ₁₀ injected i.v. rapidly attained and maintained for a long time high levels in plasma, myocardium, brain, liver, and kidneys. This was potentially important for treating acute ischemic states.