Synthesis and Antibacterial and Immunobiological Activity of Ethyl-1-(4-Aminosulfonylphenyl)-5-Aryl-3-Hydroxy-2-Oxo-3-Pyrroline-4-Carboxylates

V. L. Gein; O. V. Bobrovskaya; T. F. Odegova; I. V. Krylova; O. N. Gein; E. É. Sopova; S. V. Gein

doi:10.1007/s11094-016-1351-z

Synthesis and Antibacterial and Immunobiological Activity of Ethyl-1-(4-Aminosulfonylphenyl)-5-Aryl-3-Hydroxy-2-Oxo-3-Pyrroline-4-Carboxylates

Autores: Gein V.L.¹, Bobrovskaya O.V.¹, Odegova T.F.¹, Krylova I.V.², Gein O.N.¹, Sopova E.É.³, Gein S.V.³
Afiliações:
1. Perm State Pharmaceutical Academy, RF Ministry of Health
2. Perm State National Research University
3. Perm State Medical Academy
Edição: Volume 49, Nº 10 (2016)
Páginas: 677-679
Seção: Article
URL: https://ogarev-online.ru/0091-150X/article/view/244272
DOI: https://doi.org/10.1007/s11094-016-1351-z
ID: 244272

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A series of ethyl-1-(4-aminosulfonylphenyl)-5-aryl-3-hydroxy-2-oxo-3-pyrroline-4-carboxylates were synthesized via a three-component reaction of sodium diethyloxalylacetate and a mixture of an aromatic aldehyde and 4-aminobenzenesulfonamide. The structures of the compounds were established using IR and PMR spectroscopy and mass spectrometry. The antibacterial and immunobiological activities of the synthesized compounds were studied.