Synthesis, Structure, and Antioxidant Activity of 4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones

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Abstract

4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones were obtained by the reaction of dimethyl malonate (diethyl malonate), aromatic aldehyde, and 1H-benzimidazole-2-amine in methanol (ethanol) in the presence of piperidine for 6 h. Structure of the compounds was confirmed by 1H, 13C NMR spectroscopy and X-ray diffraction analysis. Antioxidant activity of the synthesized compounds was studied.

About the authors

K. V. Podchezertseva

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Perm, Russia

N. A. Buzmakova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Perm, Russia

T. M. Zamaraeva

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: tanyapgfa@yandex.ru
Perm, Russia

S. S. Zykova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Perm, Russia

M. V. Dmitriev

Perm State National Research University

Perm, Russia

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