Synthesis, Structure and Analgesic Activity of N-Alkyl-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides

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Abstract

A series of new N-alkyl-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides were obtained by decyclization of 4-arylamino-2-tert-butyl-2,5-dihydro-5-oxofuran-2-yl acetates under the action of aliphatic amines. The analgesic activity of the synthesized compounds was studied.

About the authors

O. V. Zvereva

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: zvereva.olga.2019@inbox.ru
Perm, Russia

E. S. Limansky

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Perm, Russia

S. V. Chashchina

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation; Perm State National Research University

Perm, Russia; Perm, Russia

I. N. Chernov

National Research Nizhny Novgorod State University named after N. I. Lobachevsky

Nizhny Novgorod, Russia

I. G. Mokrushin

Perm State National Research University

Perm, Russia

N. M. Igidov

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Perm, Russia

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