NOVEL PHOTOSENSITIZERS BASED ON CATIONIC meso-ARYLPORPHYRINS WITH THE EXTENDED π-SYSTEM

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Abstract

New photosensitizers based on cationic porphyrins with an extended π-system have been synthesized. The synthetic strategy involves the use of the Sonogashira cross-coupling reaction to form a conjugated π-system of the macrocycle. The obtained compounds exhibit an absorption peak at 660 nm with an extinction coefficient of ~60 000 M–1 cm–1; the singlet oxygen quantum yield and the 1-octanol/water partition coefficient were also determined. Absorption in the near-infrared region allows considering the obtained compounds as potential photosensitizers for photodynamic therapy.

About the authors

I. O Savelyeva

MIREA- Russian University of Technology, Institute of Fine Chemical Technology

Email: inga.saveleva.96@mail.ru
Moscow, Russia

V. A Govor

MIREA- Russian University of Technology, Institute of Fine Chemical Technology

Moscow, Russia

K. A Zhdanova

MIREA- Russian University of Technology, Institute of Fine Chemical Technology

Moscow, Russia

N. A Bragina

MIREA- Russian University of Technology, Institute of Fine Chemical Technology

Moscow, Russia

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