Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains  in vitro  due to zinc(II) complexation

Т. М. Garaev; Гараев Т. М.; I. I. Yudin; Юдин И. И.; N. V. Breslav; Бреслав Н. В.; Т. Е. Savochkina; Савочкина Т. Е.; А. S. Krepkaya; Крепкая А. С.; Т. V. Grebennikova; Гребенникова Т. В.; S. Е. Nikiforova; Никифорова С. Е.; I. I. Myshletsov; Мышлецов И. И.; V. V. Avdeeva; Авдеева В. В.; Е. А. Malinina; Малинина Е. А.

doi:10.31857/S0044457X24050113

Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation

作者: Garaev Т.М.¹, Yudin I.I.¹, Breslav N.V.¹, Savochkina Т.Е.¹, Krepkaya А.S.¹, Grebennikova Т.V.¹, Nikiforova S.Е.², Myshletsov I.I.², Avdeeva V.V.², Malinina Е.А.²
隶属关系:
1. National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
2. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
期: 卷 69, 编号 5 (2024)
页面: 736-742
栏目: КООРДИНАЦИОННЫЕ СОЕДИНЕНИЯ
URL: https://ogarev-online.ru/0044-457X/article/view/270844
DOI: https://doi.org/10.31857/S0044457X24050113
EDN: https://elibrary.ru/YEWODX
ID: 270844

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This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral low-molecular agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used in the form of zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of an influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.

关键词

influenza A, antiviral activity, water solubility, zinc, L-amino acids, aromatic carboxylic acids

参考

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卷 70, 编号 3 (2025)

Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation

全文:

详细

关键词

作者简介

Т. Garaev

I. Yudin

N. Breslav

Т. Savochkina

А. Krepkaya

Т. Grebennikova

S. Nikiforova

I. Myshletsov

V. Avdeeva

Е. Malinina

参考

补充文件