Experience in treatment of diffuse hair loss

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Abstract

Diffuse hair loss refers to non-scarring hair loss caused by various reasons. Despite the variety of etiological factors that can cause hair loss, these types of alopecies share a common characteristic: cessation of hair growth during the anagen phase. The variety of underlying causes of hair loss in these forms of alopecia complicates both therapy choice and clinical management. In this article the authors share their own clinical experience in treating such patients. Modern drugs and topical agents allow for maximum results with the absence of side effects. Treatment efficacy was assessed by clinical tests (visual examination and pull test assessment), as well as objective diagnostic methods, including trichoscopy using TrichoSciencePro software, trichogram and phototrichogram. Two clinical cases with treatment of patients with telogen effluvium are presented.

About the authors

Anastasia N. Mareeva

Central Institute Dermatocosmetology

Email: nastasya_66@mail.ru

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Yulia A. Gallyamova

Russian Medical Academy of Continuous Professional Education

Author for correspondence.
Email: 89161704546@mail.ru
ORCID iD: 0000-0002-1674-3007
SPIN-code: 5601-1201

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

References

  1. Sinclair R. Diffuse hair loss. Int J Dermatol. 1999;38(Suppl 1):8–18. doi: 10.1046/j.1365-4362.1999.00003.x
  2. Kunz M, Seifert B, Trüeb RM. Seasonality of hair shedding in healthy women complaining of hair loss. Dermatology. 2009;219(2):105–110. doi: 10.1159/000216832
  3. Blume-Peytavi U, Tosti A, Whiting DA, Trüeb R, eds. Hair growth and disorders. Berlin: Springer; 2008. Р. 259–272.
  4. Беречикидзе Т.Т., Пинегин В.Б. Диффузная телогеновая алопеция. Новые возможности коррекции. Российский журнал кожных и венерических болезней. 2016;19(3):162–166. [Berechikidze TT, Pinegin VB. Telogen effluvium. New possibilities of correction. Russian Journal of Skin and Venereal Diseases (Rossiyskii Zhurnal Kozhnykh i Venericheskikh Boleznei). 2016;19(3):162–166. (In Russ.)] doi: 10.18821/1560-9588-2016-19-3-162-166
  5. Malkud S. Telogen Effluvium: A Review. J Clin Diagn Res. 2015;9(9):WE01–WE03. doi: 10.7860/JCDR/2015/15219.6492
  6. Shrivastava SB. Diffuse hair loss in adult female: approach to diagnosis and management. Indian J Dermatol Venereol Leprol. 2009;75(1):20–27. doi: 10.4103/0378-6323.45215
  7. Grover C, Khurana A. Telogen effluvium. Indian J Dermatol Venereol Leprol. 2013;79(5):591–603. doi: 10.4103/0378-6323.116731
  8. Wadhwa SL, Khopkar U, Nischal KC. Hair and scalp disorders. In: Valia RG, Valia AR, eds. IADVL Text book of dermatology. 3rd ed. Mumbai: Bhalani Publishing House; 2010. Р. 864–948.
  9. Poonia K, Thami GP, Bhalla M, Jaiswal S, Sandhu J. NonScarring Diffuse Hair Loss in Women: a Clinico-Etiological Study from tertiary care center in North-West India. J Cosmet Dermatol. 2019;18(1):401–407. doi: 10.1111/jocd.12559
  10. Урюпина Е.Л. Хроническое телогеновое выпадение волос: научное обоснование дифференцированного подхода к тактике ведения пациентов: автореф. … канд. мед. наук. Екатеринбург; 2022. 28 с. [Uryupina EL. Hronicheskoe telogenovoe vypadenie volos: nauchnoe obosnovanie differencirovannogo podhoda k taktike vedeniya pacientov: avtoref. … kand. med. nauk. Ekaterinburg; 2022. 28 s. (In Russ.)]
  11. Whiting DA. Chronic telogen effluvium: increased scalp hair shedding in middle-aged women. J Am Acad Dermatol. 1996;35(6):899–906. doi: 10.1016/s0190-9622(96)90113-9
  12. Malkud S. A Hospital-based Study to Determine Causes of Diffuse Hair Loss in Women. J Clin Diagn Res. 2015;9(8):WC01– WC04. doi: 10.7860/JCDR/2015/14089.6170
  13. Ваньо С., Хаэн П. Трихология: практическое пособие #TrichoHRC: пер. с англ. / под ред. Т.В. Силюк. М.: Изд. дом «Косметика и медицина»; 2021. 224 с. [Van’o S., Haen P. Trihologiya: prakticheskoe posobie #TrichoHRC: per. s angl. / pod red. TV Silyuk. Moscow: Izd. dom “Kosmetika i medicina”; 2021. 224 s. (In Russ.)]
  14. Hadshiew IM, Foitzik K, Arck PC, Paus R. Burden of hair loss: stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia. J Invest Dermatol. 2004;123(3):455–457. doi: 10.1111/j.0022-202X.2004.23237.x
  15. McDonald KA, Shelley AJ, Colantonio S, Beecker J. Hair pull test: Evidence-based update and revision of guidelines. J Am Acad Dermatol. 2017;76(3):472–477. doi: 10.1016/j.jaad.2016.10.002
  16. Снарская Е.С., Гришина В.Б. Диффузная алопеция и метод ее комплексной коррекции. Российский журнал кожных и венерических болезней. 2015;18(4):49–55. [Snarskaya ES, Grishina VB. Diffuse alopecia and a method for its complex correction. Rossiyskiyzhurnal kozhnykh i venericheskikh bolezney. 2015;18(4):49–55. (In Russ.)] doi: 10.17816/dv37005
  17. Галлямова Ю.А., Кораблева О.А., Доскина Е.В., Ходова О.О. Выпадение волос в период менопаузы: пути решения проблемы. Эффективная фармакотерапия. 2020;16(27):10–14. [Gallyamova YuA, Korableva OA, Doskina YeV, Khodova OO. Hair Loss During Menopause: Ways of the Problem Solution. 2020;16(27):10–14. (In Russ.)] doi: 10.33978/2307-3586-2020-16-27-10-14
  18. Кубанов А.А., Галлямова Ю.А., Кораблева О.А. Изменения процессов регуляции ритма смены волос у женщин с нерубцующимися алопециями. Вестник дерматологии и венерологии. 2018;94(5):39–49. [Kubanov AA, Gallyamova YuA, Korableva OA. Changes in the hair growth cycle in women with non-scarring alopecia. Vestnik Dermatologii i Venerologii. 2018;94(5):39–49. (In Russ.)] doi: 10.25208/0042-4609-2018 94-5-39-4
  19. Bergfeld WF. Chapter 9. Telogen effluvium. In: McMichael J, Hordin MK, eds. Hair and Scalp Diseases: Medical, Surgical, and Cosmetic Treatments. London, UK: Informa Health Care; 2008. Р. 119–136.
  20. Buhl AE. Minoxidil’s action in hair follicles. J Invest Dermatol. 1991;96(5):73S–74S. doi: 10.1111/1523-1747.ep12471911
  21. Garg S, Manchanda S. Platelet-rich plasma — an “Elixir” for treatment of alopecia: personal experience on 117 patients with review of literature. Stem Cell Investigation. 2017;4:64. doi: 10.21037/sci.2017.06.07
  22. El-Dawla RE, Abdelhaleem M, Abdelhamed A. Evaluation of the safety and efficacy of platelet-rich plasma in the treatment of female patients with chronic telogen effluvium: A randomised, controlled, double-blind, pilot clinical trial. Indian J Dermatol Venereol Leprol. 2023;89(2):195–203. doi: 10.25259/IJDVL_1011_20
  23. Khattab FM, Rady A, Khashaba SA. Recent modalities in treatment of telogen effluvium: Comparative study. Dermatol Ther. 2022;35(10):e15720. doi: 10.1111/dth.15720
  24. Райцева С.С. Консолидированная оценка эффективности терапевтических стратегий Лабораторий Filorga в трихологиию. Трихология. 2017;1:54–61. [Rajceva SS. Konsolidirovannaya ocenka effektivnosti terapevticheskih strategij Laboratorij Filorga v trihologiiyu. Trihologiya. 2017;1:54–61. (In Russ.)]
  25. Ihrisky SA. Mesotherapy in trichology. Čas Lék Česk. 2017;156(3):145–146.
  26. Cavallini M, Bartoletti E, Maioli L, Massirone A, Pia Palmieri I, Papagni M, et al. Consensus report on the use of PN-HPT™ (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021;20(3):922–928. doi: 10.1111/jocd.13679
  27. Starace M, Alessandrini A, Brandi N, Piraccini BM. Preliminary results of the use of scalp microneedling in different types of alopecia. J Cosmet Dermatol. 2020;19(3):646–650. doi: 10.1111/jocd.13061
  28. Trüeb RM, Starace MVR, Piraccini BM, Rezende HD, Reis Gavazzoni Dias MF. Trichodynia Revisited. Skin Appendage Disord. 2021;7(6):449–453. doi: 10.1159/000517463

Supplementary files

Supplementary Files
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1. JATS XML
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2. Fig. 1. Patient М. before treatment: a — thinning of hair in the temporal region; б — decrease the hair density; в — trichoscopic picture

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3. Fig. 2. Patient М. after treatment: a — the growth of hair in the temporal region; б — increase the hair density; в — trichoscopic picture

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4. Fig. 3. Patient A. before treatment: a — thinning of hair in the temporal region; б — trichoscopic picture

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5. Fig. 4. Patient A. after treatment: a — the growth of hair in the temporal region; б — trichoscopic picture

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Copyright (c) 2025 Mareeva A.N., Gallyamova Y.A.

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