Psoriasis in pediatric dermatological clinical practice: diagnosis and management

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Abstract

The relevance of this topic is confirmed by the widespread psoriasis prevalence. Psoriasis in children has severe forms growth and diagnostic difficulties. It is crucially important to examine histologically the skin especially in pediatric dermatological clinical practice. According to our observations Pityriasis Rubra Pilaris has become one of the most frequent dermatoses with which differential diagnosis of psoriasis has to be carried out. A clinical dermatosis observation in a 13-year-old girl is described. The disease was similar to the manifestations of Pityriasis Rubra Pilaris. The results of the affected skin biopsy study did not exclude this diagnosis. The clinical and morphological manifestations of the dermatosis could be effected by steroid therapy. Subsequent dynamic observation and histological examination allowed us to diagnose psoriasis. Current data is collected and presented. The choice of external therapy in pediatric practice is a controversial topic. Clinical results of the Activated Zinc Pyrithion external forms use in the psoriasis treatment are presented.

About the authors

Olga A. Sidorenko

Rostov State Medical University

Author for correspondence.
Email: ola_ps@mail.ru
ORCID iD: 0000-0002-7387-2497
SPIN-code: 2209-0521

MD, Dr. Sci. (Med.), Professor

Russian Federation, Rostov-on-Don

Liudmila A. Anisimova

Rostov State Medical University

Email: 4373764@mail.ru
ORCID iD: 0000-0002-9696-9179
SPIN-code: 2770-1394

MD, Cand. Sci. (Med.), Associate Professor

Russian Federation, Rostov-on-Don

Vyacheslav V. Starostenko

Rostov State Medical University

Email: star-vycheslav@yandex.ru
ORCID iD: 0000-0002-1755-366X
SPIN-code: 8368-1695

MD, Cand. Sci. (Med.), Associate Professor

Russian Federation, Rostov-on-Don

Svetlana V. Grebennikova

Don State Technical University

Email: svetgrva@yandex.ru
ORCID iD: 0000-0001-9158-271X
SPIN-code: 9657-1974

Cand. Sci. (Pharm.), Associate Professor

Russian Federation, Rostov-on-Don

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2. Fig. 1. Histological examination of a skin biopsy, stained with hematoxylin and eosin (× 200): 1 — follicular hyperkeratosis, enlarged hair follicle; 2 — mild uneven acanthosis; 3 — granular layer preserved; 4 — edema of the dermal papillae; 5 — perivascular lymphohistiocytic infiltrate

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3. Fig. 2. 13-year-old patient before the first histological examination

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4. Fig. 3. The same patient before the second histological examination

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5. Fig. 4. Histological examination of a skin biopsy, stained with hematoxylin and eosin (× 200): 1 — Munro’s microabscess; 2 — psoriasiform acanthosis; 3 — agranulosis; 4 — capillary proliferation; 5 — perivascular lymphohistiocytic infiltrate with neutrophils

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Copyright (c) 2024 Sidorenko O.A., Anisimova L.A., Starostenko V.V., Grebennikova S.V.

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