Grover’s disease — current understanding of transient and persistent acantholytic dermatosis
- Authors: Chepushtanova K.O.1, Patrushev A.V.1, Gorbunov Y.G.1, Belousova I.E.1
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Affiliations:
- S.M. Kirov Military Medical Academy
- Issue: Vol 100, No 3 (2024)
- Pages: 17-25
- Section: REVIEWS
- URL: https://ogarev-online.ru/0042-4609/article/view/262334
- DOI: https://doi.org/10.25208/vdv16048
- ID: 262334
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Abstract
Grover’s disease is a papulo-vesicular pruritic dermatosis characterized by a transient, persistent, or asymptomatic course. We have analyzed the publications found in the PubMed and RSCI scientific literature databases between 1970 and 2022. The clinical manifestations of Grover’s disease, possible localization, etiological factors, and the histological and dermatoscopic picture of the disease are described. According to the literature, the putative associations with disease onset are highly variable and include insolation, pregnancy, hemodialysis, chemotherapy, sweating, a number of dermatoses, and a history of malignancy and organ transplantation. Seasonality of the process has also been described. To date, nine histologic patterns of the disease have been described, the most common being acantholytic dyskeratosis.
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##article.viewOnOriginalSite##About the authors
Kseniya O. Chepushtanova
S.M. Kirov Military Medical Academy
Author for correspondence.
Email: kseniyachepushtanova@mail.ru
ORCID iD: 0000-0001-6883-0762
SPIN-code: 5037-7208
Russian Federation, Saint Petersburg
Aleksandr V. Patrushev
S.M. Kirov Military Medical Academy
Email: alexpat2@yandex.ru
ORCID iD: 0000-0002-6989-9363
SPIN-code: 1367-5580
MD, Dr. Sci. (Med.)
Russian Federation, Saint PetersburgYuri G. Gorbunov
S.M. Kirov Military Medical Academy
Email: urikgor@rambler.ru
ORCID iD: 0000-0002-1375-056X
SPIN-code: 3393-3256
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgIrena E. Belousova
S.M. Kirov Military Medical Academy
Email: irena.belousova@mail.ru
ORCID iD: 0000-0002-9458-0872
SPIN-code: 2287-5062
MD, Dr. Sci. (Med.), Professor
Russian Federation, Saint PetersburgReferences
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Fig. 1. Disseminated papulo-vesicular rashes in the abdominal area
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Fig. 2. Disseminated papulo-vesicular rashes in the chest area
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Fig. 3. Disseminated papulo-vesicular rashes in the back area
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Fig. 4. Darye-like histological variant of Grover’s disease: acantholytic dyskeratosis with dyskeratotic cells in the upper epidermis
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Fig. 5. Pemphigus-like variant of Grover’s disease: suprabasal acantholysis with the formation of cracks in the epidermis. A large diceratotic cell is visible (arrow)
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Fig. 6. Hayley–Hayley is a similar variant of Grover’s disease: acanthosis in the epidermis, acantholysis phenomena of the «crumbling brick wall» type
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Fig. 7. Combination of two histological subtypes in one patient. Two seropapules located side by side were taken for biopsy, in one of them a spongiotic subtype was observed with the formation of an intraepidermal cavity (insert), in the second — a pemphigus-like one with the formation of a suprabasal acantholytic cavity (insert)
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Рис. 8. Элемент на коже груди в виде папулы диаметром 5 мм. Определяется бесструктурная зона коричневого цвета в центре (синяя стрелка), окруженная белым ореолом (красная стрелка)
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Fig. 9. An element on the breast skin in the form of a papule with a diameter of 7 mm. A small number of diffusely arranged white scales on a red-yellow background, as well as point and linear vessels with a reticular distribution, are determined
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