The role of exosomes in the diagnostics and treatment of immune mediated skin disoders, wounds and alopecia

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Abstract

Exosomes are microvesicles secreted by different cells that have the specificity and ability to transfer their cargo, including various regulatory molecules, to other cells. Exosomes cargo analysis considered to be a promising approach for diagnostics and therapeutic agents delivery into cells. Molecules derived from exosome cargo supposed to be plausible diagnostics criteria. This review provides up-to-date information on the exosomes origin and composition followed by a description of their diagnostic potential. New data summarized on the possibilities of exosomes application for the treatment of chronic immune-mediated cutaneous disorders, alopecia and cutaneous wound healing.

About the authors

Nadezhda V. Palkina

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: mosmannv@yandex.ru
ORCID iD: 0000-0002-6801-3452
SPIN-code: 7534-4443
ResearcherId: P-1585-2015

MD, Dr. Sci. (Med.), Professor

Russian Federation, Krasnoyarsk

Revaz D. Zenaishvili

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: ya.zrevaz@yandex.ru

PhD, Student

Russian Federation, Krasnoyarsk

Tatiana G. Ruksha

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Author for correspondence.
Email: tatyana_ruksha@mail.ru
ORCID iD: 0000-0001-8142-4283
SPIN-code: 5412-2148

MD, Dr. Sci. (Med.), Professor

Russian Federation, Krasnoyarsk

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2. Fig. 1. Stages of exosome biogenesis

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3. Fig. 2. Promising directions for the use of exosomes in the diagnosis and treatment of dermatological diseases

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Copyright (c) 2024 Palkina N.V., Zenaishvili R.D., Ruksha T.G.

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