Vulvar lichen planus — clinical spectrum (results of a cross-sectional uncontrolled study)
- 作者: Parygina O.V.1,2, Smirnova I.О.1,2,3, Petunova Y.G.1,2, Kabushka Y.S.1, Zhelonkin A.R.1,2
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隶属关系:
- City Dermatovenereological Dispensary
- Saint Petersburg State University
- North-Western State Medical University named after I.I. Mechnikov
- 期: 卷 98, 编号 4 (2022)
- 页面: 49-57
- 栏目: ORIGINAL STUDIES
- URL: https://ogarev-online.ru/0042-4609/article/view/117628
- DOI: https://doi.org/10.25208/vdv1326
- ID: 117628
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Background. Lichen planus (LP) is a chronic dermatosis, which can affect vulva. Currently, there are no sufficient data about clinical picture of vulvar LP and a valuation combined lesion on the vulva, oral mucous and smooth skin in patients with different forms of LP.
Aims. Is to study the features of the vulvar LP clinical picture.
Materials and methods. A cross-sectional (simultaneous) uncontrolled study of 46 patients with vulvar LP was performed. We assessed the structure of vulvar LP, the duration and the manifestation of disease, localization of lesions, the involvement of the skin and oral mucosa. LichenSclerosus-Square was used to assess the area of lesions in vulvar LP.
Results. The erosive form dominated in the structure of vulvar LP morbidity, which was diagnosed in 73,9% of cases. The process in erosive and hypertrophic form of LP was more common than in the typical form of LP. Distinctive features of the erosive form of the disease were the involvement of the inner surfaces of the labia minora and the vestibule (73,5% и 70,6%, p < 0,001). The erosive LP is also characterized by a damage of normal vulvar architectonics (58,8%, p = 0,007).
Lesions in typical LP affected labia majora (66,7%) and labia minora (33,4%), and to a lesser extent the commissure posterior (16,7%). The involvement of labia majora was found in all patients with hypertrophic form LP. The involvement of inguinal folds distinguished the hypertrophic form from other forms of LP and was observed in 33,4% of patients.
Vulva lesions without the involvement of the skin and mucous membranes of other localizations were more typical for patients with erosive and hypertrophic LP (35,4% и 33,3%). Almost half of the patients (47,0%) with erosive LP had the involvement of mucous membranes, 29,0% of them were diagnosed with vulvovaginal-gingival syndrome. In 14.7% of cases, vulvovaginal-gingival syndrome combined with lesions in the scalp (vulvovaginal-gingival-pillar syndrome).
Conclusions. We have identified clinical features of different forms of vulvar LP, which can be used for differential diagnosis.
作者简介
Olga Parygina
City Dermatovenereological Dispensary; Saint Petersburg State University
编辑信件的主要联系方式.
Email: olga.parygina@bk.ru
ORCID iD: 0000-0003-2056-9803
SPIN 代码: 4637-4938
dermatovenerologist in outpatient department, teacher in Medicine College
俄罗斯联邦, 3, Vollovka River Emb., Saint Petersburg, 192102; 7-9, Universitetskaya Emb., Saint Petersburg, 199034Irina Smirnova
City Dermatovenereological Dispensary; Saint Petersburg State University; North-Western State Medical University named after I.I. Mechnikov
Email: driosmirnova@yandex.ru
ORCID iD: 0000-0001-8584-615X
SPIN 代码: 5518-6453
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, 3, Vollovka River Emb., Saint Petersburg, 192102; 7-9, Universitetskaya Emb., Saint Petersburg, 199034; 41, Kirochnaya str., Saint Petersburg, 191015Yanina Petunova
City Dermatovenereological Dispensary; Saint Petersburg State University
Email: yaninapetunova@yandex.ru
ORCID iD: 0000-0002-6489-4555
SPIN 代码: 5853-9630
MD, Cand, Sci. (Med.)
俄罗斯联邦, 3, Vollovka River Emb., Saint Petersburg, 192102; 7-9, Universitetskaya Emb., Saint Petersburg, 199034Yana Kabushka
City Dermatovenereological Dispensary
Email: gorkvd@zdrav.spb.ru
ORCID iD: 0000-0002-9825-4038
MD, Cand. Sci. (Med.)
俄罗斯联邦, 3, Vollovka River Emb., Saint Petersburg, 192102Anton Zhelonkin
City Dermatovenereological Dispensary; Saint Petersburg State University
Email: goodtony@yandex.ru
ORCID iD: 0000-0001-9013-3197
SPIN 代码: 3507-5623
Postgraduate Student, Department of Infectious Diseases, Epidemiology and Dermatovenereology
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