Pagetoid reticulosis
- Authors: Sergeeva E.Y.1, Khorzhevskii V.A.1, Ruksha T.G.1
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Affiliations:
- Krasnoyarsk State Medical University
- Issue: Vol 97, No 6 (2021)
- Pages: 81-86
- Section: GUIDELINES FOR PRACTITIONERS
- URL: https://ogarev-online.ru/0042-4609/article/view/117588
- DOI: https://doi.org/10.25208/vdv1239
- ID: 117588
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Abstract
Pagetoid reticulosis (PR) is a rare type of mycosis fungoides. Clinical symptoms of PR can mimic other skin diseases of papulosquamous, neoplastic, and infectious origin that hampers PR diagnostics. The main histopathologic feature of PR is dense intraepidermal infiltration by medium to large-size lymphocytes through the epidermis leading to pagetoid plaque formation. There are three common immunophenotypes of PR: CD4-positive T-helper phenotype (CD3+, CD4+, CD8–); T-cytotoxic/suppressor (CD3+, CD4–, CD8+); and double negative phenotype (CD3+, CD4–, CD8–). The clinical case of PR with rare immunophenotype (CD2+, CD3+, CD8+ lymphoid infiltrate) is presented. The careful analysis of the symptoms, pathomorphological and immunohistochemical data is necessary for accurate PR diagnostics.
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##article.viewOnOriginalSite##About the authors
Ekaterina Yu. Sergeeva
Krasnoyarsk State Medical University
Email: e.ya.sergeeva@mail.ru
ORCID iD: 0000-0002-2089-6022
к.м.н.
Russian Federation, Partizana Zheleznyaka str., 1, 660022, KrasnoyarskVladimir A. Khorzhevskii
Krasnoyarsk State Medical University
Email: vladpatholog@yandex.ru
ORCID iD: 0000-0002-9196-7246
MD, Cand. Sci. (Med.)
Russian Federation, Partizana Zheleznyaka str., 1, 660022, KrasnoyarskTatiana G. Ruksha
Krasnoyarsk State Medical University
Author for correspondence.
Email: tatyana_ruksha@mail.ru
ORCID iD: 0000-0001-8142-4283
MD, Dr. Sci. (Med.), Professor
Russian Federation, Partizana Zheleznyaka str., 1, 660022, KrasnoyarskReferences
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