Modern understanding of the pathogenesis of basal cell skin cancer

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Abstract

The incidence of basal cell skin cancer is increasing worldwide. The initiation and progression of basal cell skin cancer is due to the interaction of environmental factors and the patient's genetic characteristics. Aberrant activation of the transmission of the Hedgehog signaling pathway is the main pathogenetic pathway of carcinogenesis.

Since basal cell skin cancer is manifested by significant variability of morphological structure, aggressiveness and response to treatment, the disclosure of the molecular genetics of pathogenesis will become the basis for developing new approaches and increasing the effectiveness of treatment, as well as overcoming tumor resistance to treatment.

To search for the necessary literature, the PubMed, MedLine, Web of Science and RSCI databases were used.

About the authors

R. R. Saytburkhanov

State Research Center of Dermatovenereology and Cosmetology

Email: rifat03@yandex.ru
ORCID iD: 0000-0001-6132-5632
SPIN-code: 1149-2097

dermatovenereologis

Russian Federation, Moscow

A. A. Kubanov

State Research Center of Dermatovenereology and Cosmetology

Email: alex@cnikvi.ru
ORCID iD: 0000-0002-7625-0503
SPIN-code: 8771-4990

MD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences

Russian Federation, Moscow

I. N. Kondrakhina

State Research Center of Dermatovenereology and Cosmetology

Email: kondrakhina77@gmail.com
ORCID iD: 0000-0003-3662-9954
SPIN-code: 8721-9424

MD, Cand. (Sci.) Med.

Russian Federation, Moscow

X. I. Plakhova

State Research Center of Dermatovenereology and Cosmetology

Author for correspondence.
Email: plahova@cnikvi.ru
ORCID iD: 0000-0003-4169-4128
SPIN-code: 7634-5521

MD, Dr. Sci. (Med.)

Russian Federation, Moscow

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2. Fig. 1. Physiological Hedgehog signaling pathway [79]. Description in text

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3. Fig. 2. Ligand-dependent or receptor-induced activation of the Hedgehog signaling pathway in the development of basal cell skin cancer. Activated or inactivated pathways are reported in red or green, respectively. Description in text [79]

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4. Fig. 3. Alternative activation of the Hedgehog signaling pathway in the development of basal cell skin cancer [79]. Activated or inactivated pathways are reported in red or green, respectively. Description in text

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5. Fig. 4. Mutations in other genes involved in the pathogenesis of basal cell skin cancer [79]. Activated or inactivated pathways are reported in red or green, respectively. Description in text

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Copyright (c) 2021 Saytburkhanov R.R., Kubanov A.A., Kondrakhina I.N., Plakhova X.I.

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