Skin cytokine profile in patients with mycosis fungoides
- Authors: Karamova A.E.1, Nikonorov A.А.1, Verbenko D.A.1, Znamenskaya L.F.1, Vorontsova A.1
-
Affiliations:
- State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
- Issue: Vol 96, No 6 (2020)
- Pages: 14-19
- Section: ORIGINAL STUDIES
- URL: https://ogarev-online.ru/0042-4609/article/view/117501
- DOI: https://doi.org/10.25208/vdv1202
- ID: 117501
Cite item
Full Text
Abstract
Aim of the study. To determine the concentration of cytokines in the skin of patients with mycosis fungoides and correlations between their concentration and the value of the modified scale for assessing the severity of skin lesions mSWAT.
Methods. The concentration of cytokines was simultaneously determined using xMAP technology: IL-1â, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL -31, IL-33, IFN-ã, sCD40L, TNF-á in skin biopsies of 21 patients with early (IA—IIA) stages of mycosis fungoides and 4 healthy individuals. Analysis and visualization of the obtained data were carried out using R Statistical Software for MacOS (version 1.3.1056), a free open source software development environment for the R programming language.
Results. An increase in the level of IL-4 and TNF-á in the lesions in patients with mycosis fungoides compared with healthy individuals was shown (p = 0.025 and p = 0.012, respectively). Correlation analysis revealed the formation of cytokine networks in the skin of patients with mycosis fungoides that were not associated with the value of the modified scale for assessing the severity of skin lesions mSWAT. A tendency towards a negative relationship between the mSWAT and IFNã scales was found (p = 0.056).
Conclusion. None of the cytokines in lesions and visually unaffected skin from patients with mycosis fungoides were associated with mSWAT values.
Full Text
##article.viewOnOriginalSite##About the authors
Arfenya E. Karamova
State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: karamova@cnikvi.ru
ORCID iD: 0000-0003-3805-8489
SPIN-code: 3604-6491
MD, Cand. Sci. (Med.)
Russian Federation, Korolenko str., 3, bldg 6, Moscow, 107076, RussiaAlexandr А. Nikonorov
State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
Email: nikonorov_all@mail.ru
ORCID iD: 0000-0001-7214-8176
SPIN-code: 3859-7081
MD, Dr. Sci. (Med.), Professor
Russian Federation, Korolenko str., 3, bldg 6, Moscow, 107076, RussiaDmitry A. Verbenko
State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
Email: verbenko@gmail.com
ORCID iD: 0000-0002-1104-7694
SPIN-code: 8261-6561
Cand. Sci. (Biol.)
Russian Federation, Korolenko str., 3, bldg 6, Moscow, 107076, RussiaLyudmila F. Znamenskaya
State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
Email: znaml@cnikvi.ru
ORCID iD: 0000-0002-2553-0484
SPIN-code: 9552-7850
MD, Dr. Sci. (Med.)
Russian Federation, Korolenko str., 3, bldg 6, Moscow, 107076, RussiaAnastasiia Vorontsova
State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
Email: vorontsova@cnikvi.ru
ORCID iD: 0000-0002-3129-0050
SPIN-code: 8334-2890
junior research associate
Russian Federation, Korolenko str., 3, bldg 6, Moscow, 107076, RussiaReferences
- Willemze R, Cerroni L, Kempf W, et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood.2019;133(16):1703–1714. doi: 10.1182/blood-2018-11-881268
- Jawed SI, Myskowski PL, Horwitz S, et al. Primary cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers. J Am AcadDermatol 2014 Feb; 70(2):205; e1–16. PMID: 24438969 doi: 10.1016/j.jaad.2013.07.049
- Matutes E. The 2017 WHO update on mature T- and natural killer (NK) cell neoplams. Int J LabHematol 2018 May;40(1):97–103. PMID: 29741263. doi: 10.1111/ijlh.12817
- Olsen EA, Whittaker S, Kim YH, et al. International Society for Cutaneous Lymphomas; United States Cutaneous Lymphoma Consortium; Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer. Clinical end points and response criteria in mycosis fungoides and Sézary syndrome: a consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer. J Clin Oncol. 2011;29(18):2598–2607. doi: 10.1200/JCO.2010.32.0630
- Stevens SR, Ke MS, Parry EJ, et al. Quantifying skin disease burden in mycosis fungoides-type cutaneous T-cell lymphomas: The severity-weighted assessment tool (SWAT) Arch Dermatol. 2002;138: 42–48.
- Guenova E, Watanabe R, Teague JE, et al. TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma. Clin Cancer Res 2013; 19:3755–3763. PMID: 23785046. doi: 10.1158/1078-0432.CCR-12-3488
- Wolk K, Mitsui H, Witte K, et al. Deficient cutaneous antibacterial competence in cutaneous T-cell lymphomas: role of Th2-mediated biased Th17 function. Clin Cancer Res 2014; 20 (21):5507–16.PMID: 25212608. doi: 10.1158/1078-0432.CCR-14-0707
- Amitay-Laish I, Guenova E, Ortiz-Romero PL, et al. The Course of Mycosis Fungoides under Cytokine Pathway Blockers: A Multicentre Analysis of Real-life Clinical Data. Acta Dermato-Venereologica. 2020 Sep;100(16):adv00277. doi: 10.2340/00015555-3642
- Harrington LE, Mangan PR, Weaver CT. Expanding the effector CD4 Tcell repertoire: the Th17 lineage. Curr Opin Immunol 2006;18:349–56
- Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation. J Clin Invest 2006;116:1218–22.
- Duhen T, Geiger R, Jarrossay D, et al. Production of interleukin 22 but not interleukin 17 by a subset of human skinhoming memory T cells. Nat Immunol 2009;10:857–63. 31
- Eyerich S, Eyerich K, Pennino D, et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009;119:3573–85.
- Krejsgaard T, Ralfkiaer U, Clasen-Linde E, et al. Malignant cutaneous T-cell lymphoma cells express IL-17 utilizing the Jak3/Stat3 signaling pathway. J Invest Dermatol 2011; 131(6):1331–8. PMID: 21346774. doi: 10.1038/jid.2011.27
- Krejsgaard T, Litvinov IV, Wang Y, et al. Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma. Blood 2013;122:943–950. PMID: 23801634. doi: 10.1182/blood-2013-01-480889
- Yoo J, Shah F, Velangi S, et al. Secukinumab for treatment of psoriasis: does secukinumab precipitate or promote the presentation of cutaneous T-cell lymphoma? Clin Exp Dermatol 2019; 44: 414–417, 35–38.
- Wolk K, Mitsui H, Witte K, et al. Deficient cutaneous antibacterial competence in cutaneous T-cell lymphomas: Role of Th2-mediated biased Th17 function. Clin Cancer Res 2014; 20; 5507–5516.
- Miyagaki T, Sugaya M, Suga H, et al. IL-22, but Not IL-17, dominant environment in cutaneous T-cell lymphoma. Clin Cancer Res 2011; 17; 7529–7538.
- Duhen T, Geiger R, Jarrossay D, et al. Production of interleukin 22 but not interleukin 17 by a subset of human skinhoming memory T cells. Nat Immunol 2009;10:857–63. 31
- Eyerich S, Eyerich K, Pennino D, et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009;119:3573–85.
- Miyagaki T, Sugaya M, Suga H, et al. IL-22, but Not IL-17, Dominant Environment in Cutaneous T-cell Lymphoma. Clin Cancer Res 2011;17:7529–7538. Published OnlineFirst November 2, 2011.
- Olsen E, Vonderheid E, Pimpinelli N, et al. Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: A proposal of the International Sosiety for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood. 2007;110:1713–1722]. [The Modified Severity-Weighted Assessment Tool: A PASI/EASI System for Mycosis Fungoides FR-mSWAT: el “PASI/EASI” de la micosis fungoides A. Combalia, T. Estrach Actas Dermosifiliogr. 2018;109(8):745–746.
Supplementary files
