Selection of the therapy of herpes viral infection based on the data of the monitoring of the sensitivity of the herpes simplex virus to etiotropic drugs
- 作者: Alimbarova LM1, Lazarenko AA1, Barinsky IF1
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隶属关系:
- ФБГУ «Научно-исследовательский институт вирусологии им. Д.И. Ивановского» Минздравсоцразвития России
- 期: 卷 88, 编号 2 (2012)
- 页面: 21-25
- 栏目: Articles
- URL: https://ogarev-online.ru/0042-4609/article/view/117106
- DOI: https://doi.org/10.25208/vdv662
- ID: 117106
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全文:
详细
The authors present the results of the monitoring of the sensitivity of herpes simplex virus (HSV) strains in vitro isolated from 110 female patients with various forms of the herpes virus infection to etiotropic drugs (acyclovir (ACV)), valacyclovir) based on the data provided by the phenotypic method. The authors established that 90% of HSV strains were sensitive to ACV irrespective of the isolation conditions, and the share of non-sensitive strains was 10% while the share of strains that were not sensitive to valacyclovir was not higher than 0.9%. These data are of great value for the evaluation of the pathological process activity, forecast for the disease and selection of an individualized treatment regimen for patients providing for the selection of an antiviral drug and its optimum dose in view of the results of virology studies.
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作者简介
L Alimbarova
ФБГУ «Научно-исследовательский институт вирусологии им. Д.И. Ивановского» Минздравсоцразвития России
Email: virology@mail.ru
ведущий научный сотрудник Москва
A Lazarenko
ФБГУ «Научно-исследовательский институт вирусологии им. Д.И. Ивановского» Минздравсоцразвития Россииведущий научный сотрудник Москва
I Barinsky
ФБГУ «Научно-исследовательский институт вирусологии им. Д.И. Ивановского» Минздравсоцразвития Россиируководитель лаборатории Москва
参考
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- Agut H., Boutolleau D., Deback C. et al. Testing the susceptibility of human herpesviruses to an-tivirals. Future Microbiol 2009; 4: 1111—1123.
- Алимбарова Л.М., Лазаренко А.А., Баринский И.Ф. Культуральный метод в диагностике герпесвирусных инфекций. Инфекционные болезни 2010; 8: 3: 24—28.
- Swierkosz E.M., Hodinka R. L., Moore B. M. et al. Antiviral susceptibility testing: herpes simplex virus by plaque reduction assay. Approved standart. Clinical and Laboratory Standards Institute 2004; 24 (7): 1—39.
- ФГУ «ЦНИИОИЗ Минздравсоцразвития РФ» — www.mednet.ru
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