A case of Kaposi’s sarcoma: using immunohistochemistry studies to identify human herpes virus of the 8th type


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Abstract

The article discusses problems related to optimizing differential diagnostics of Kaposi’s sarcoma using the immunohistochemistry analysis, in particular, identification of human herpes virus of the 8th type being the causative agent of the development of the disease.

About the authors

T G RUKSHA

Krasnoyarsk State Medical University; Krasnoyarsk Territorial Clinical Hospital

Email: tatyana_ruksha@mail.ru
д.м.н., зав. кафедрой патофизиологии

M B AKSENENKO

Krasnoyarsk State Medical University

к.м.н., ассистент кафедры патофизиологии

V A KHORZHEVSKY

Krasnoyarsk Territorial Pathological Anatomy Bureau

к.м.н., зам. начальника

S S BEKAZUROV

Krasnoyarsk Territorial Pathological Anatomy Bureau

начальник

References

  1. Дерматовенерология, 2010 [под ред. А.А. Кубановой М.: ДЭКС-ПРЕСС, 2010
  2. Chang Y., Cesarman E., Pessin M.S. et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994; 266: 1865-1869
  3. Ganem D. KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. J Clin Invest 2010; 120: 939-949
  4. Weninger W., Partanen T.A., Breiteneder-Geleff S. et al. Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi’s sarcoma tumor cells. Lab Invest 1999; 79: 243-251
  5. Nuovo M., Nuovo J. Utility of HHV8 detection for differentiating Kaposi’s sarcoma from it’s mimics. J Cutan Pathol 2001; 28: 248-255
  6. Patel R.M., Goldblum J.R., Hsi E.D. Immunohistochemical detection of human herpes virus-8 latent nuclear antigen-1 is useful in the diagnosis of Kaposi sarcoma. Mod Pathol 2004; 17: 456-460

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Copyright (c) 2013 RUKSHA T.G., AKSENENKO M.B., KHORZHEVSKY V.A., BEKAZUROV S.S.

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