Association of polymorphisms in TNFAIP3 and TNIPI genes with predisposition to the development of psoriasis in the Russian population
- Authors: KUBANOV AA1, KOZHUSHNAYA OS1, FRIGO NV1, MINEYEVA AA1, ZNAMENSKAYA LF1, CHIKIN VV1
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Affiliations:
- State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
- Issue: Vol 89, No 6 (2013)
- Pages: 49-53
- Section: Articles
- URL: https://ogarev-online.ru/0042-4609/article/view/117071
- DOI: https://doi.org/10.25208/vdv589
- ID: 117071
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Abstract
Goal. To study polymorphisms in TNFAIP3 (rs610604) and TNIPI (rs17728338) genes in a sample of psoriasis patients and healthy volunteers from the Russian Federation. Materials and methods. By using allele specific hybridization methods in the form of real-time PCR and RFLP assay (Restriction Fragment Length Polymorphism), single-nucleotide polymorphisms of fragments of the following genes associated with predisposition to the development of psoriasis were studied in whole blood samples taken from psoriasis patients (n = 286) and healthy volunteers (n = 89): TNFAIP3 (rs610604) and TNIPI (rs17728338). Results. Psoriasis patients had a reliable increase in the frequency of the A/C heterozygous genotype of rs610604 polymorphism of the TNFAIP3 gene and A allele of rs17728338 polymorphism of the TNIP1 gene (A/G and A/A genotypes), which makes it possible to treat carriers of these genotypes as people with predisposition to the development of psoriasis, and to treat A/C genotypes of rs610604 polymorphism and A/G and A/A genotypes of rs17728338 polymorphism as predictors of the development of psoriasis in the Russian population. Conclusion. these data broaden the perception of genetic factors associated with the development of psoriasis in persons from the Russian population.
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##article.viewOnOriginalSite##About the authors
A A KUBANOV
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federationд.м.н., профессор, зам. директора по научной работе
O S KOZHUSHNAYA
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federationмладший научный сотрудник отделения молекулярных методов диагностики ИППП и болезней кожи
N V FRIGO
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federationд.м.н., зам. директора по научно-образовательной работе
A A MINEYEVA
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
Email: mineeva@cnikvi.ru
младший научный сотрудник отдела дерматологии
L F ZNAMENSKAYA
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federationк.м.н., зав. отделом дерматологии
V V CHIKIN
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federationк.м.н., старший научный сотрудник отдела дерматологии
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