Email this article Maturation of oocytes in vitro: biological basis and prospects for clinical use
- Authors: Drobintseva A.O.1, Frolov V.K.1, Bogolyubova I.O.1,2, Savelyeva O.E.1, Kuleva S.A.1
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Affiliations:
- Saint Petersburg State Pediatric Medical University
- Institute of Cytology, Russian Academy of Sciences
- Issue: Vol 67, No 2 (2025)
- Pages: 65-79
- Section: Articles
- URL: https://ogarev-online.ru/0041-3771/article/view/306206
- DOI: https://doi.org/10.31857/S0041377125020015
- EDN: https://elibrary.ru/FVHJIV
- ID: 306206
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Abstract
In vitro oocyte maturation (IVM) involves the aspiration of prophase I oocytes in oocyte-cumulus complexes from small antral follicles and their subsequent maturation to metaphase II (MII). IVM is a promising method for obtaining MII oocytes in cases where hormonal stimulation of the ovaries is undesirable or impossible. At the same time, in terms of maturation rates and developmental capacity, oocytes obtained as a result of the IVM procedure are inferior to oocytes obtained in stimulated cycles; therefore, improving IVM protocols is a hot topic. The review discusses the possibilities of the IVM procedure in the context of key stages of oocyte maturation and their achievement of nuclear and cytoplasmic maturity. The advantages and disadvantages of various IVM techniques and the main directions for their further improvement are highlighted.
About the authors
A. O. Drobintseva
Saint Petersburg State Pediatric Medical University
Email: ao.drobintseva@gpmu.org
Saint Petersburg, 194100, Russia
V. K. Frolov
Saint Petersburg State Pediatric Medical University
Email: ao.drobintseva@gpmu.org
Saint Petersburg, 194100, Russia
I. O. Bogolyubova
Saint Petersburg State Pediatric Medical University; Institute of Cytology, Russian Academy of Sciences
Email: ibogol@mail.ru
Saint Petersburg, 194100, Russia; Saint Petersburg, 194064, Russia
O. E. Savelyeva
Saint Petersburg State Pediatric Medical University
Email: ao.drobintseva@gpmu.org
Saint Petersburg, 194100, Russia
S. A. Kuleva
Saint Petersburg State Pediatric Medical University
Author for correspondence.
Email: ao.drobintseva@gpmu.org
Saint Petersburg, 194100, Russia
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