The effect of AntiAGE-Biom probiotic on metabolic features in individuals with type 2 diabetes

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Abstract

Background. Despite the variety of antidiabetic therapies, many patients with type 2 diabetes (T2D) do not achieve optimal glycemic control. Therefore, there is a need to develop additional methods for managing T2D, including ones that regulate the gut microbiome.

Aim. To assess the effect of AntiAGE-Biom probiotic on metabolic parameters in T2D patients during 3 months of therapy.

Materials and methods. A randomized, double-blind, placebo-controlled, single-center study included patients with T2D with glycated hemoglobin – HbA1c<7,5% on stable antidiabetic therapy. Patients were randomized into groups receiving AntiAGE-Biom and placebo. The primary endpoint was the change in HbA1c from baseline, secondary endpoints included the dynamics in biochemical and anthropometric parameters, body composition, as well as HOMA-IR index.

Results. The study included 40 patients with T2D (n=20 in each group). There was a trend towards a decrease in HbA1c in AntiAGE-Biom group, that did not reach statistical significance. The use of the probiotic improved the body composition after 3 months: reduced the percentage of fat in men and a subgroup of patients with an initial HbA1c≥ 6.5%; also increased skeletal muscle mass and lean mass in the trunk segment in men (р<0,05).

Conclusion. AntiAGE-Biom probiotic helps to maintain metabolic control and significantly improve body composition in T2D patients with initial HbA1c<7.5%.

About the authors

Ekaterina A. Shestakova

Endocrinology Research Centre; Russian Medical Academy of Continuous Professional Education

Author for correspondence.
Email: katiashestakova@mail.ru
ORCID iD: 0000-0001-6612-6851

д-р мед. наук, гл. науч. сотр., проф. каф. эндокринологии

Russian Federation, Moscow; Moscow

Anastasiia V. Nosova

Endocrinology Research Centre

Email: katiashestakova@mail.ru
ORCID iD: 0009-0002-4590-644X

врач-диетолог

Russian Federation, Moscow

Fatima Kh. Dzgoeva

Endocrinology Research Centre

Email: katiashestakova@mail.ru
ORCID iD: 0000-0002-7314-9063

канд. мед. наук, зав. отд. по оказанию диетологической помощи

Russian Federation, Moscow

Sabina A. Nurmamedova

Endocrinology Research Centre

Email: katiashestakova@mail.ru
ORCID iD: 0009-0002-7153-6681

ординатор-диетолог

Russian Federation, Moscow

Nadezhda V. Frolkova

Endocrinology Research Centre

Email: katiashestakova@mail.ru
ORCID iD: 0009-0001-6204-4231

аспирант

Russian Federation, Moscow

Ekaterina E. Mishina

Endocrinology Research Centre

Email: katiashestakova@mail.ru
ORCID iD: 0000-0002-5371-8708

канд. мед. наук, науч. сотр.

Russian Federation, Moscow

Marina V. Shestakova

Endocrinology Research Centre

Email: katiashestakova@mail.ru
ORCID iD: 0000-0002-5057-127X

акад. РАН, д-р мед. наук, проф., дир. Института диабета, зам. дир.

Russian Federation, Moscow

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2. Fig. 1. HbA1c change in AntiAGE-Biom and placebo groups during 3 months of the study, %.

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3. Fig. 2. HbA1c change in subgroups with HbA1c≥6,5% and <6,5%, %.

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4. Fig. 3. Body composition change in subgroups with HbA1c≥6,5% and <6,5%: a – body fat mass (%) change; b – skeletal muscle mass change; c – trunk lean mass change.

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5. Fig. 4. HbA1c in men and women, %.

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6. Fig. 5. Body composition change in men and women: a – body fat mass (%) change; b – skeletal muscle mass change; c – trunk lean mass change.

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