OCT Study of Optical Clearing of Muscle Tissue in vitro with 40% Glucose Solution


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Resumo

The technique of -optical clearing of biological tissues- is aimed at improving the quality of visualization of structures hidden deep in tissue. In this study, we measured the diffusion coefficient of glucose in bovine skeletal muscle tissue by optical coherence tomography (OCT) in vitro and determined changes that took place in the imaging contrast of muscle fibers, the optical depth of coherent probing, and detection under the influence of aqueous 40% solution of glucose. It was shown that, within 90 min, when the depth of coherent probing increased by 14%, the contrast of OCT images increased fourfold and the depth of coherent detection of structural elements of the tissue increased by 2.4 times. The diffusion coefficient of glucose in the muscle tissue was (2.98 ± 0.94) × 10-6 cm2/s.

Sobre autores

E. Genina

Chernyshevskii Saratov State University; Tomsk State University

Autor responsável pela correspondência
Email: eagenina@yandex.ru
Rússia, Saratov, 410012; Tomsk, 634050

A. Bashkatov

Chernyshevskii Saratov State University; Tomsk State University

Email: eagenina@yandex.ru
Rússia, Saratov, 410012; Tomsk, 634050

M. Kozintseva

Chernyshevskii Saratov State University

Email: eagenina@yandex.ru
Rússia, Saratov, 410012

V. Tuchin

Chernyshevskii Saratov State University; Tomsk State University; Institute of Precision Mechanics and Control

Email: eagenina@yandex.ru
Rússia, Saratov, 410012; Tomsk, 634050; Saratov, 410028

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