Search for Potential Epitopes in the Envelope Protein of the African Swine Fever Virus

Capa

Citar

Texto integral

Resumo

The spatial structure of the envelope protein of African swine fever (ASF) virus is modeled; its topology relative to the cell membrane is calculated; the B- and T-cell epitopes are predicted for this protein; and their immunogenecity, allergenicity, and toxicity are estimated. The variability of protein amino acids and the conservativity of the found epitopes are studied. It is shown that a new peptide vaccine against ASF can be developed based on the found epitopes.

Sobre autores

I. Kolesnikov

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

V. Timofeev

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia; Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

A. Ermakov

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

A. Ivanovsky

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

Yu. Dyakova

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

Yu. Pisarevsky

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia; National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

M. Kovalchuk

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia; Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

Autor responsável pela correspondência
Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

Bibliografia

  1. Mettenleiter T.C., Sobrino F. // Animal Viruses: Molecular Biology. 2008. V. 14. P. 5. https://doi.org/10.3201/eid1405.080077
  2. Anderson E.C., Hutchings G.H., Mukarati N., Wilkinson P.J. // Veterinary Microbiology. 1998. V. 62 (1). P. 1. https://doi.org/10.1016/S0378-1135(98)00187-4
  3. Khomenko S., Beltrán-Alcrudo D., Rozstalnyy A. et al. // Empress Watch. 2013. V. 28. P. 1
  4. Mazur-Panasiuk N., Woźniakowski G., Niemczuk K. // Sci Rep. 2019. V. 9. № 4556. https://doi.org/10.1038/s41598-018-36823-0
  5. Colson P., De Lamballerie X., Yutin N. et al. // Arch Virol. 2013. V. 158. P. 2517. https://doi.org/10.1007/s00705-013-1768-6
  6. Dixon L.K., Chapman D.A., Netherton C.L., Upton C. // Virus Res. 2013. V. 173 (1). P. 3.
  7. Netherton C.L., Wileman T.E. // Virus Res. 2013. V. 173 (1). P. 76. https://doi.org/10.1016/j.virusres.2012.12.014
  8. Gaudreault N.N., Madden D.W., Wilson W.C. et al. // Front. Vet. Sci. 2020. V. 7. 215. https://doi.org/10.3389/fvets.2020.00215
  9. Rodríguez J.M., Yáñez R.J., Almazán F. et al. // J. Virol. 1993. V. 67. № 9. P. 5312. https://doi.org/10.1128/jvi.67.9.5312-5320.1993
  10. Ruiz-Gonzalvo F., Rodríguez F., Escribano J.M. // Virology. 1996. V. 218 (1). P. 285. https://doi.org/10.1006/viro.1996.0193
  11. Abass O.A., Timofeev V.I., Sarkar B. et al. // J. Biomol. Struct. Dynamics. 2021. V. 40 (16). P. 7283. https://doi.org/10.1080/07391102.2021.1896387
  12. Araf Y., Moin A.T., Timofeev V.I. et al. // Front. Immunol. 2022. V. 13. 863234. https://doi.org/10.3389/fimmu.2022.863234
  13. Q89501. https://nbgi.ru/
  14. Altschul S.F., Gish W., Miller W. et al. // J. Mol. Biol. 1990. V. 215 (3). P. 403.
  15. Jumper J., Evans R., Pritzel A. et al. // Nature. 2021. V. 596. P. 583. https://doi.org/10.1038/s41586-021-03819-2
  16. Jeppe H., Trigos K.D., Pedersen M.D. et al. // bioRxiv. 2022. https://doi.org/10.1101/2022.04.08.487609
  17. Larsen M.V., Lundegaard C., Lamberth K. et al. // BMC Bioinformatics. 2007. V. 8. 424. https://doi.org/10.1186/1471-2105-8-424
  18. http://tools.iedb.org/ellipro/
  19. Ponomarenko J., Bui HH., Li W. et al. // BMC Bioinformatics. 2008. V. 9. 514. https://doi.org/10.1186/1471-2105-9-514
  20. Dimitrov I., Bangov I., Flower D.R. et al. // J. Mol. Model. 2014. V. 20 (5). 2278. https://doi.org/10.1007/s00894-014-2278-5
  21. Gupta S., Kapoor P., Chaudhary K. et al. // PLoS ONE. 2020. V. 8 (9). e73957. https://doi.org/10.1371/journal.pone.0073957
  22. Doytchinova I.A., Flower D.R. // BMC Bioinformatics. 2007. V. 8. 4. https://doi.org/10.1186/1471-2105-8-4
  23. Bui H., Sidney J.H., Li W. et al. // BMC Bioinformatics. 2007. V. 8 (1). 361. https://doi.org/10.1186/1471-2105-8-361
  24. Larsen M.V., Lundegaard C., Lamberth K. et al. // BMC Bioinformatics. 2007. V. 8. 424. https://doi.org/10.1186/1471-2105-8-424
  25. Choo S.Y. // Yonsei Med J. 2007. V. 48 (1). P. 11. https://doi.org/10.3349/ymj.2007.48.1.11
  26. Potocnakova L., Bhide M., Pulzova L.B. // J. Immunol. Res. 2016. https://doi.org/10.1155/2016/6760830

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML
Baixar
2.

Baixar (259KB)
Metadados
3.

Baixar (31KB)
Metadados
4.

Baixar (181KB)
Metadados
5.

Baixar (190KB)
Metadados

Declaração de direitos autorais © Russian Academy of Sciences, 2023

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).