Отправить статью по E-mail Effect of chronic fluoxetine treatment on audiogenic epilepsy, symptoms of anxiety and depression in rats of four lines
- Авторы: Sarkissova K.Y.1, Fedotova I.B.2, Surina N.M.2, Nikolaev G.M.2, Perepelkina O.V.2, Poletaeva I.I.2
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Учреждения:
- Institute of Higher Nervous Activity and Neurophysiology, RAS
- Moscow State University
- Выпуск: Том 467, № 1 (2016)
- Страницы: 55-58
- Раздел: Physiology
- URL: https://ogarev-online.ru/0012-4966/article/view/153652
- DOI: https://doi.org/10.1134/S0012496616020058
- ID: 153652
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Аннотация
Anxiety (Anx) and depression (Dp) levels were evaluated in rats of 4 lines: 2 of them (KM and “4”) exhibited audiogenic seizures (AS), and 2 (Wistar and “0”) had no AS. In KM rats (with AS), Anx and Dp levels were higher than in Wistars (without AS), while in “4” and “0” rats with the related genetic background but contrasting in AS severity, Anx and Dp indices were not different. Fluoxetine treatment exerted antidepressant effect in all rat lines irrespective of its effect on AS. Thus, phenotypic expression of AS is not directly associated with the mechanisms of Anx and Dp development.
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K. Sarkissova
Institute of Higher Nervous Activity and Neurophysiology, RAS
Email: ingapoletaeva@mail.ru
Россия, Moscow
I. Fedotova
Moscow State University
Email: ingapoletaeva@mail.ru
Россия, Moscow
N. Surina
Moscow State University
Email: ingapoletaeva@mail.ru
Россия, Moscow
G. Nikolaev
Moscow State University
Email: ingapoletaeva@mail.ru
Россия, Moscow
O. Perepelkina
Moscow State University
Email: ingapoletaeva@mail.ru
Россия, Moscow
I. Poletaeva
Moscow State University
Автор, ответственный за переписку.
Email: ingapoletaeva@mail.ru
Россия, Moscow
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