Email this article Effect of chronic fluoxetine treatment on audiogenic epilepsy, symptoms of anxiety and depression in rats of four lines
- Authors: Sarkissova K.Y.1, Fedotova I.B.2, Surina N.M.2, Nikolaev G.M.2, Perepelkina O.V.2, Poletaeva I.I.2
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Affiliations:
- Institute of Higher Nervous Activity and Neurophysiology, RAS
- Moscow State University
- Issue: Vol 467, No 1 (2016)
- Pages: 55-58
- Section: Physiology
- URL: https://ogarev-online.ru/0012-4966/article/view/153652
- DOI: https://doi.org/10.1134/S0012496616020058
- ID: 153652
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Abstract
Anxiety (Anx) and depression (Dp) levels were evaluated in rats of 4 lines: 2 of them (KM and “4”) exhibited audiogenic seizures (AS), and 2 (Wistar and “0”) had no AS. In KM rats (with AS), Anx and Dp levels were higher than in Wistars (without AS), while in “4” and “0” rats with the related genetic background but contrasting in AS severity, Anx and Dp indices were not different. Fluoxetine treatment exerted antidepressant effect in all rat lines irrespective of its effect on AS. Thus, phenotypic expression of AS is not directly associated with the mechanisms of Anx and Dp development.
About the authors
K. Yu. Sarkissova
Institute of Higher Nervous Activity and Neurophysiology, RAS
Email: ingapoletaeva@mail.ru
Russian Federation, Moscow
I. B. Fedotova
Moscow State University
Email: ingapoletaeva@mail.ru
Russian Federation, Moscow
N. M. Surina
Moscow State University
Email: ingapoletaeva@mail.ru
Russian Federation, Moscow
G. M. Nikolaev
Moscow State University
Email: ingapoletaeva@mail.ru
Russian Federation, Moscow
O. V. Perepelkina
Moscow State University
Email: ingapoletaeva@mail.ru
Russian Federation, Moscow
I. I. Poletaeva
Moscow State University
Author for correspondence.
Email: ingapoletaeva@mail.ru
Russian Federation, Moscow
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