Effect of polypeptides from sea anemone Heteractis crispa on the rodent blood pressure, heart rate, and hemostasis


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АРНС1–3 peptides, modulators of TRPV1 receptors, have been administered to SD rats to study their influence on the animal hemostatic system, heart rate, and blood pressure. None of АЗРС1–3 polypeptides have any effect on the hemostatic system. Both АРНС1 and АРНС2 polypeptides increased significantly the heart rate, but they did not affect blood pressure, which was probably caused by an ability of these polypeptides to modify animal thermoregulation.

Sobre autores

L. Skobtsova

Pushchino Branch, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Pushchino State Institute of Natural Sciences

Email: dyachenko@bibch.ru
Rússia, Pushchino, Moscow oblast; Pushchino, Moscow oblast

I. Dyachenko

Pushchino Branch, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Pushchino State Institute of Natural Sciences

Autor responsável pela correspondência
Email: dyachenko@bibch.ru
Rússia, Pushchino, Moscow oblast; Pushchino, Moscow oblast

Ya. Andreev

Shemyakm–Ovchinnikov Institute of Bioorganic Chemistry

Email: dyachenko@bibch.ru
Rússia, Moscow

Yu. Logashina

Shemyakm–Ovchinnikov Institute of Bioorganic Chemistry

Email: dyachenko@bibch.ru
Rússia, Moscow

A. Murashev

Pushchino Branch, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Pushchino State Institute of Natural Sciences

Email: dyachenko@bibch.ru
Rússia, Pushchino, Moscow oblast; Pushchino, Moscow oblast

E. Grishin

Shemyakm–Ovchinnikov Institute of Bioorganic Chemistry

Email: dyachenko@bibch.ru
Rússia, Moscow

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