Metformin inhibits development of colon malignant tumors induced by 1,2-dimethylhydrazine in rats

V. M. Patsanovskii; A. D. Nozdrachev; V. N. Anisimov; V. V. Bekusova

doi:10.1134/S0012496616030017

Metformin inhibits development of colon malignant tumors induced by 1,2-dimethylhydrazine in rats

Authors: Patsanovskii V.M.¹, Nozdrachev A.D.², Anisimov V.N.³, Bekusova V.V.²
Affiliations:
1. Pavlov Institute of Physiology
2. St. Petersburg State University
3. Petrov Research Institute of Oncology
Issue: Vol 468, No 1 (2016)
Pages: 97-100
Section: Physiology
URL: https://ogarev-online.ru/0012-4966/article/view/153700
DOI: https://doi.org/10.1134/S0012496616030017
ID: 153700

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Abstract

It has been shown that metformin dose-dependently inhibits the development of colon tumors induced by 1,2-dimethylhydrazine (DMH) in rats. The metformin effect manifested itself as a decrease in the amount and average size of tumors, increased degree of their differentiation, and reduction of invasion depth, which was more pronounced in the group of animals that received metformin at a dose of 100 mg/kg of body weight as compared with rats treated with metformin at a dose of 300 mg/kg.